9 Results for "

paralytic

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "paralytic" in MCE Product Catalog:

製品番号: HY-135000
CAS 番号: 58911-04-9
別名: DcSTX; DecarbamoylSTX
Decarbamoylsaxitoxin is a sodium channel inhibitor that blocks the influx of sodium ions through the membranes of excitable nerves and skeletal muscle cells, thereby preventing the formation of action potentials. Decarbamoylsaxitoxin is an acidic hydrolysis product of saxitoxin, and its toxic effects on mice are identical to those of saxitoxin. Decarbamoylsaxitoxin inhibits veratridine- and ouabain-induced swelling and lysis of mouse neuroblastoma cells by blocking Na + channels. Decarbamoylsaxitoxin can be used in studies related to paralytic shellfish poisoning .
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製品番号: HY-137252
CAS 番号: 73162-95-5
別名: Ivermectin Impurity G
Target:  

Parasite

研究分野:  

Infection

22,23-Dihydroavermectin B1a aglycon is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
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製品番号: HY-19605
CAS 番号: 60508-89-6
Target:  

Sodium Channel

研究分野:  

Neurological Disease Cancer

Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease .
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製品番号: HY-N6609
CAS 番号: 6801-40-7
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .
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製品番号: HY-124874
CAS 番号: 195966-93-9
別名: (rel)-Aspergillimide; (rel)-VM55598
Target:  

nAChR

(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms .
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製品番号: HY-W343059
CAS 番号: 60537-65-7
別名: GTX-III
Target:  

Sodium Channel

研究分野:  

Neurological Disease Cancer

Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease .
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製品番号: HY-P5176
別名: LtTx-1a
Target:  

ペプチド

研究分野:  

Neurological Disease

Latartoxin-1a (LtTx-1a) is a peptide toxin can be isolated from L. tarabaevi. Latartoxin-1a is paralytic and lethal to insects and has membrane-bound activity .
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製品番号: HY-179116
別名: BS2463
Target:  

Parasite

研究分野:  

Infection

BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection .
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製品番号: HY-N6609B
CAS 番号: 75413-87-5
Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .
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