BL-1005
BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H17ClF2N4OS
- 分子量:422.88
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
BL-1005 (0.02-50 μM; 48 h) reduces cell viability in HEK293, HeLa and HepG2 cells with a CC50 of 37.3, 21.3 and 22.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Note | Cmax | T1/2 |
|---|---|---|---|---|---|
| Mice | 2.5 mg/kg | i.p. | 文献审核 | 247.3 ng/mL | 1.51 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Schistosoma mansoni (adult and juvenile, 28-42-day-old)[1]
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Dosage:0.6 μM, 1.2 μM
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Administration:2 h
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Result:Induced a sustained paralysis in both adult and juvenile S. mansoni, with partial recovery of motility over 9 days.
化学情報
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分子量 422.88
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分子式 C19H17ClF2N4OS
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SMILES
FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4
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別名
BS2463
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BL-1005 関連分類
HY-179116 関連分類
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