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製品番号: HY-184247

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SR-32685

SR-32685 is a NAMPT activator and neuroprotective agent. SR-32685 enhances the enzymatic activity of hNAMPT, prevents intracellular NAD depletion, and protects neurons from death induced by toxic misfolded prion proteins. SR-32685 can be used in the research of protein misfolding neurodegenerative diseases and metabolic diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2791469-14-0
分子式: C₂₂H₂₄N₆O₂S
分子量:436.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-32685 構造式

CAS 番号: 2791469-14-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SR-32685 protects neuronal cells against TPrP-induced death with an EC₅₀ of 40 nM^[1].
SR-32685 (1 μM) increases the activity of h-NAMPT by at least 10% at a concentration of 1 μM^[1].
SR-32685 exhibits a stability of more than 15 min in h-microsome (liver)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2791469-14-0
分子量 436.53
分子式 C₂₂H₂₄N₆O₂S
SMILES

O=C(C(C=NN12)=C2NC(C3=CC=C(OCC)C=C3)=CC1=S)NCCCN4C=CN=C4C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Thomas D. Bannister, et al. Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders. WO2022133303A1. WIPO (PCT). 2021-12-17.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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