SRI-37264
SRI-37264 is a HIV-1 Nef inhibitor with a Kd value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2358714-71-1
- 分子式: C17H14ClN3O3S
- 分子量:375.83
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
SRI-37264 (3-48 h) inhibits Nef-dependent HIV-1 infectivity in TZM-bl cells with an IC50 of 0.32 μM and has no detectable cytotoxicity (CC50 > 100 μM)[1].
SRI-37264 (1.0 μM; 24 h) partially restores cell-surface MHC-I expression by 15.9% in HIV-1-infected primary HLA-A2+ CD8-depleted PBMCs[1].
SRI-37264 (125 μM; 25 min) at a 5-fold molar excess disrupts preformed recombinant Nef-CD·AP-1 μ1 complexes in solution[1].
SRI-37264 has excellent metabolic stability with a half-life > 2 h in mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 |
|---|---|---|---|
| Mice[1] | 1 mg/kg | i.v. | 40 min |
化学情報
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CAS 番号 2358714-71-1
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分子量 375.83
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分子式 C17H14ClN3O3S
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SMILES
O=C1C2=CC=CN=C2SN1C3=CC=C(C(C(N4CCOCC4)=O)=C3)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SRI-37264 関連分類
HY-184379 関連分類
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