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United States

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製品番号: HY-P12128

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SYN1753

SYN1753 is a selective inhibitor of human neonatal Fc receptor (hFcRn) with a K_d value of 0.5 μM. SYN1753 binds to the albumin-binding site of hFcRn, inhibits the hFcRn-albumin interaction, and thereby suppresses FcRn-mediated transcytosis of human albumin. SYN1753 can be used in studies related to acetaminophen-induced liver injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₉₉H₁₃₇N₂₇O₂₅S₂
分子量:2169.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYN1753 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

hFcRn

0.5 μM (Kd)

体外実験

SYN1753 is a specific peptide inhibitor of the human FcRn-albumin interaction that binds to the albumin-specific epitope on FcRn, with a K_d of 0.5 μM at pH 6.0^[1].
SYN1753 inhibits hFcRn-mediated albumin transcytosis in polarized MDCK II cells^[1].
SYN1753 (1 mM; 1 h) binds to a shared site on recombinant shFcRn/β2m molecules, forming a stable complex with intramolecular disulfide bonds and putative hydrogen bonds^[1].
SYN1753 inhibits the transcytosis of human albumin in both basolateral-to-apical and apical-to-basolateral directions in MDCK II cells co-expressing hFcRn and hβ2m^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

化学情報

分子量 2169.44
分子式 C₉₉H₁₃₇N₂₇O₂₅S₂
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H]([C@H](O)C)C(N)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(NCC(N[C@H]3CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
配列

Ac-Arg-Tyr-Phe-Cys-Thr-Lys-Trp-Lys-His-Gly-Trp-Cys-Glu-Glu-Val-Gly-Thr-NH2 (disulfide bridge:Cys4-Cys12)
シーケンスの短縮

Ac-RYFCTKWKHGWCEEVGT-NH2 (disulfide bridge:Cys4-Cys12)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pyzik M, et al. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 04;114(14):E2862-E2871. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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