Tempone-15N,d16
Based on 1 Customer Validation
Tempone-15N,d16 (4-Oxo-Tempo 15N,D16) is the deuterated, 15N-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.86%
- CAS 番号: 80404-14-4
- 分子式: 15NC9D16O2
- 分子量:187.32
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 80404-14-4
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非標識Cas 2896-70-0
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性状 Solid
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分子量 187.32
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分子式 15NC9D16O2
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Color Light yellow to yellow
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SMILES
[O][15N]1C(C([2H])([2H])[2H])(C([2H])([2H])C(C([2H])([2H])C1(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C([2H])([2H])[2H]
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別名
4-Oxo-Tempo-15N,d16
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 30 mg/mL (160.15 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (284 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicological sciences : an official journal of the Society of Toxicology. 2018 May 01;163(1):214-225. [Content Brief]
[7]. Patel NS, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. Free radical biology & medicine. 2002 Dec 01;33(11):1575-89. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3385 mL | 26.6923 mL | 53.3846 mL | 133.4615 mL |
| 5 mM | 1.0677 mL | 5.3385 mL | 10.6769 mL | 26.6923 mL | |
| 10 mM | 0.5338 mL | 2.6692 mL | 5.3385 mL | 13.3461 mL | |
| 15 mM | 0.3559 mL | 1.7795 mL | 3.5590 mL | 8.8974 mL | |
| 20 mM | 0.2669 mL | 1.3346 mL | 2.6692 mL | 6.6731 mL | |
| 25 mM | 0.2135 mL | 1.0677 mL | 2.1354 mL | 5.3385 mL | |
| 30 mM | 0.1779 mL | 0.8897 mL | 1.7795 mL | 4.4487 mL | |
| 40 mM | 0.1335 mL | 0.6673 mL | 1.3346 mL | 3.3365 mL | |
| 50 mM | 0.1068 mL | 0.5338 mL | 1.0677 mL | 2.6692 mL | |
| 60 mM | 0.0890 mL | 0.4449 mL | 0.8897 mL | 2.2244 mL | |
| 80 mM | 0.0667 mL | 0.3337 mL | 0.6673 mL | 1.6683 mL | |
| 100 mM | 0.0534 mL | 0.2669 mL | 0.5338 mL | 1.3346 mL |
Tempone-15N,d16 関連分類
HY-129242S 関連分類
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