TLR4 agonist-2
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research.
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- CAS 番号: 2148927-98-2
- 分子式: C31H30N4O2S
- 分子量:522.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hTLR4 0.82 μM (EC50) |
mTLR4 0.43 μM (EC50) |
TLR4 agonist-2 (Compound 36) (5 μM; overnight) potently induces the release of IL-6 and CCL5 from primary mouse bone marrow-derived dendritic cells[1].
TLR4 agonist-2 potently induces the release of IL8 and IL-6 from primary human peripheral blood mononuclear cells[1].
TLR4 agonist-2 (5 μM; overnight) shows no significant toxicity to human hepatocellular carcinoma cells HepG2 at the concentration of 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 human hepatocellular carcinoma cells
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Concentration:5 μM
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Incubation Time:overnight
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Result:Showed no significant difference in cell viability compared to reference compound 1, vehicle control (DMSO), and positive controls (1Y136, LPS).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6[1]
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Dosage:20 nmol
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Administration:i.v.; single dose
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Result:Induced significantly higher serum levels of the chemokine KC (keratinocyte chemoattractant; CXCL1) and IP-10 at 3 hours post-injection.
Showed a trend toward higher serum IL-6 levels at 3 hours post-injection.
化学情報
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CAS 番号 2148927-98-2
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分子量 522.66
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分子式 C31H30N4O2S
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SMILES
CN1C2=CC=C(C=C2C3=C1C(N(C(SCC(NC4CCCCC4)=O)=N3)C5=CC=CC=C5)=O)C6=CC=CC=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TLR4 agonist-2 関連分類
HY-186271 関連分類
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- TLR4 agonist-2
- 2148927-98-2
- Toll-like Receptor (TLR)
- human TLR4
- murine TLR4 reporter cells
- HepG2 human hepatocellular carcinoma cells
- LPS binding pocket
- TLR4/MD-2 complex
- primary murine bone marrow-derived dendritic cells
- C57BL/6 mice
- primary human peripheral blood mononuclear cells
- human TLR4 reporter cells
- TLR4 signaling
- Inhibitor
- inhibitor
- inhibit