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United States

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製品番号: HY-182923

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UM-200

UM-200 is a covalent STING inhibitor with an EC₅₀ of 1.10 μM. UM-200 covalently modifies the cysteine residues C292 or C309 of STING, thereby blocking its oligomerization and downstream signal transduction. UM-200 inhibits STING-dependent phosphorylation of TBK1 and IRF3. UM-200 inhibits the STING signaling pathway in mouse models. UM-200 can be used for research on STING-driven inflammatory and autoimmune diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₄H₂₁N₅O₂S
分子量:443.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

UM-200 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

UM-200 (0.08-40 μM; 1 h pretreatment, 24 h stimulation) potently inhibits STING signaling in THP1-Dual KI-hSTING-R232 cells with an EC₅₀ of 1.10 μM^[1].
UM-200 (1 h pretreatment, 2 h stimulation) inhibits diABZI-induced IFNβ and IL6 gene transcription in immortalized bone marrow-derived macrophages^[1].
UM-200 (1 h pretreatment, 24 h stimulation) inhibits diABZI-induced IFNβ secretion in immortalized bone marrow-derived macrophages^[1].
UM-200 (2.5 μM; 1 h pretreatment, 16 h stimulation) inhibits diABZI-induced IFNβ secretion in primary human CD14+ monocytes when dosed at 2.5 μM^[1].
UM-200 (1 μM; 1 h pretreatment, 30-120 min stimulation) inhibits diABZI-induced phosphorylation of TBK1 and IRF3, and blocks STING oligomerization in wild-type bone marrow-derived macrophages when dosed at 1 μM^[1].
UM-200 (1 μM; up to 45 min) exhibits improved metabolic stability in human liver microsomes with a half-life of 77 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

wild-type bone marrow-derived macrophages (BMDMs)
Concentration:

1 μM
Incubation Time:

1 h (pretreatment); 30-120 min (stimulation with 500 nM diABZI-3)
Result:

Inhibited diABZI-induced phosphorylation of TBK1 and IRF3.
Blocked STING oligomerization, as shown by reduced STING oligomer bands in native gel immunoblots.

体内実験

UM-200 effectively inhibits STING signaling in mouse systems^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

分子量 443.52
分子式 C₂₄H₂₁N₅O₂S
SMILES

O=C(C1=CN=C(S1)C2=CC=CC=C2)N[C@H](C3=NC4=C(N3C)C=CC=C4)CCNC(C#C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Barasa L, et al. Development of UM-200: A Novel Alkyne Amide-Based Inhibitor of the cGAS-STING Pathway. J Med Chem. 2026;69(7):8561-8582. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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