製品番号: HY-N7922

Urolithin M5

(別名: Decarboxyellagic acid)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 97.31%
CAS 番号: 91485-02-8
分子式: C₁₃H₈O₇
分子量:276.20

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Urolithin M5 構造式

CAS 番号: 91485-02-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

p38 MAPK アイソフォーム固有の製品をすべて表示 :

EGFR アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

体外実験

Urolithin M5 (two-fold dilution series; 48 h) exhibits cytotoxicity against MDCK cells with a CC₅₀ of 227.4 μM^[1].
Urolithin M5 (5-500 μM; 30 min virus pre-incubation, 30 min erythrocyte incubation) does not inhibit hemagglutination induced by influenza A/WSN/33(H1N1) virus in chicken erythrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Madin-Darby canine kidney (MDCK) cells
Concentration:

10 μM, 100 μM, 1 mM
Incubation Time:

48 h
Result:

Exhibited a CC₅₀ value of 227.4 μM against madin-Darby canine kidney (MDCK) cells.

体内実験

Urolithin M5 (200 mg/kg/day; p.o.; once daily; 6 consecutive days) protects 50% of PR8-infected BALB/c mice from death, reduces lung edema and viral load, and lowers pro-inflammatory cytokine levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 16-18 g, intranasally infected with influenza A virus strain PR8)^[1]
Dosage:

200 mg/kg/day
Administration:

p.o.; once daily; 6 consecutive days
Result:

Protected 50% of mice from death.
Showed rebound in body weight starting at day 9.Reduced lung index from 1.445 to 0.8875.\n
Reduced lung viral titer by 0.52 log.Decreased lung tissue levels of NF-κB, TNF-α, and IL-6.
Alleviated histopathological lung lesions including reduced bronchial injury and inflammatory cell infiltration.

化学情報

CAS 番号 91485-02-8
性状 Solid
分子量 276.20
分子式 C₁₃H₈O₇
Color White to yellow
SMILES

O=C1C2=CC(O)=C(O)C(O)=C2C3=CC=C(O)C(O)=C3O1
別名

Decarboxyellagic acid
Structure Classification
- Phenols
- Polyphenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (362.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6206 mL

18.1028 mL

36.2056 mL

5 mM

0.7241 mL

3.6206 mL

7.2411 mL

10 mM

0.3621 mL

1.8103 mL

3.6206 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Xiao M, et al. Urolithin M5 from the Leaves of Canarium album (Lour.) DC. Inhibits Influenza Virus by Targeting Neuraminidase. Molecules. 2022 Sep 5;27(17):5724. [Content Brief]

[2]. Li HL, et al. Identification of ellagic acid and urolithins as natural inhibitors of Aβ_25-35-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking. Front Nutr. 2022;9:966276. Published 2022 Aug 2. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.6206 mL	18.1028 mL	36.2056 mL	90.5141 mL
	5 mM	0.7241 mL	3.6206 mL	7.2411 mL	18.1028 mL
	10 mM	0.3621 mL	1.8103 mL	3.6206 mL	9.0514 mL
	15 mM	0.2414 mL	1.2069 mL	2.4137 mL	6.0343 mL
	20 mM	0.1810 mL	0.9051 mL	1.8103 mL	4.5257 mL
	25 mM	0.1448 mL	0.7241 mL	1.4482 mL	3.6206 mL
	30 mM	0.1207 mL	0.6034 mL	1.2069 mL	3.0171 mL
	40 mM	0.0905 mL	0.4526 mL	0.9051 mL	2.2629 mL
	50 mM	0.0724 mL	0.3621 mL	0.7241 mL	1.8103 mL
	60 mM	0.0603 mL	0.3017 mL	0.6034 mL	1.5086 mL
	80 mM	0.0453 mL	0.2263 mL	0.4526 mL	1.1314 mL
	100 mM	0.0362 mL	0.1810 mL	0.3621 mL	0.9051 mL

Urolithin M5

1 Cited Publications

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Urolithin M5

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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MedChemExpress（MCE）の使用を引用している文献 Urolithin M5

p38 MAPK アイソフォーム固有の製品をすべて表示

EGFR アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Urolithin M5 関連分類

HY-N7922 関連分類