Vitexilactone
Based on 1 Customer Validation
Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.67%
- CAS 番号: 61263-49-8
- 分子式: C22H34O5
- 分子量:378.50
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| HCT-116 | GI50 |
>5000 ng/mL
Compound: 13
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 11975496] |
| HCT-116 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| HL-60 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| PC-12 | GI50 |
>5000 ng/mL
Compound: 13
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Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 11975496] |
| RAW264.7 | IC50 |
42.5 μM
Compound: 1
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
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[PMID: 24035341] |
| ZR-75-30 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
Vitexilactone shows significant antimicrobial activity towards E. coli with an MIC value ＞90 μg/mL[1]. Vitexilactone (0-100 μg/mL; 17-24 h) inhibits cell proliferation of mammalian cancer cells[2]. Vitexilactone (25-100 μg/mL; 17 h) induces cell apoptosis at higher concentrations, while inhibits the cell cycle G0/G1 phase at lower concentrations of tsFT210 and K562 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:tsFT210 and K562 cells lines
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Concentration:0-100 μg/mL
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Incubation Time:17-24 hours
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Result:Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.
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Cell Line:tsFT210 and K562 cell lines
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Concentration:25-100 μg/mL
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Incubation Time:17 hours
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Result:Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.
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Cell Line:tsFT210 and K562 cell lines
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Concentration:25-100 μg/mL
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Incubation Time:17 hours
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Result:Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
化学情報
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CAS 番号 61263-49-8
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性状 Solid
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分子量 378.50
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分子式 C22H34O5
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Color White to off-white
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SMILES
O=C1OCC(CC[C@@]2(O)[C@H](C)C[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CCC[C@]23C)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sichaem J, et al. A new labdane-type diterpenoid from the leaves of Vitex negundo L. Nat Prod Res. 2021 Jul;35(14):2329-2334. [Content Brief]
[2]. Li WX, et al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr;7(2):95-105. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Vitexilactone 関連分類
HY-N1079 関連分類
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