VU0546110
Based on 1 Customer Validation
VU0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3, with IC50s of 1.287 μM (SLO3) and 59.80 μM (SLO1) in HEK293 cells, respectively. VU0546110 blocks heterologous SLO3 currents and endogenous K+ currents in human sperm. VU0546110 halts sperm hyperpolarization, induced acrosome reaction, and hyper-activated motility. VU0546110 has contraceptive potential.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.47%
- CAS 番号: 1421523-00-3
- 分子式: C24H31NO4S2
- 分子量:461.64
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Membrane Transporter/Ion Channel Compound Library
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生物活性
1.287 μM (SLO3), 59.80 μM (SLO1)[1]
VU0546110 (10 μM) blocks the K+ current in human sperm at intracellular free Ca2+ concentrations of 0-50 µM[1].
VU0546110 (2.5 μM) inhibits the hyperpolarized membrane potential at pH 8.0 in human spermatozoa[1].
VU0546110 (2.5-10 μM) inhibits the hyperactivated motility and Ca2+ ionophore A23187 (HY-N6687) or progesterone (HY-N0437) induced acrosome reaction in human sperm[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1421523-00-3
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性状 Solid
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分子量 461.64
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分子式 C24H31NO4S2
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Color White to off-white
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SMILES
O=C(CC1=CC=C(S(=O)(C(C)C)=O)C=C1)N2CCC(CC2)CSC3=CC=C(C=C3)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (216.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1662 mL | 10.8310 mL | 21.6619 mL | 54.1548 mL |
| 5 mM | 0.4332 mL | 2.1662 mL | 4.3324 mL | 10.8310 mL | |
| 10 mM | 0.2166 mL | 1.0831 mL | 2.1662 mL | 5.4155 mL | |
| 15 mM | 0.1444 mL | 0.7221 mL | 1.4441 mL | 3.6103 mL | |
| 20 mM | 0.1083 mL | 0.5415 mL | 1.0831 mL | 2.7077 mL | |
| 25 mM | 0.0866 mL | 0.4332 mL | 0.8665 mL | 2.1662 mL | |
| 30 mM | 0.0722 mL | 0.3610 mL | 0.7221 mL | 1.8052 mL | |
| 40 mM | 0.0542 mL | 0.2708 mL | 0.5415 mL | 1.3539 mL | |
| 50 mM | 0.0433 mL | 0.2166 mL | 0.4332 mL | 1.0831 mL | |
| 60 mM | 0.0361 mL | 0.1805 mL | 0.3610 mL | 0.9026 mL | |
| 80 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6769 mL | |
| 100 mM | 0.0217 mL | 0.1083 mL | 0.2166 mL | 0.5415 mL |
VU0546110 関連分類
HY-164911 関連分類
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