(Z)-Semaxanib
Based on 4 publication(s) in Google Scholar
(Z)-Semaxanib ((Z)-SU5416) is a VEGF receptor tyrosine kinase inhibitor that blocks VEGF signaling through Flk-1/KDR. (Z)-Semaxanib inhibits angiogenesis by preventing new blood vessel formation. (Z)-Semaxanib induces cytotoxicity in liver cancer cells. (Z)-Semaxanib can be used in research on metastatic renal cell carcinoma, gastrointestinal stromal tumors, well-differentiated pancreatic neuroendocrine tumors, and solid tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.72%
- CAS 番号: 194413-58-6
- 分子式: C15H14N2O
- 分子量:238.29
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 (Z)-Semaxanib
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| TAMH | IC50 |
6.28 μM
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Cytotoxicity against TAMH cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity against TAMH cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
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26593399 |
| HepG2 | IC50 |
8.17 μM
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Cytotoxicity of the pure Z isomer against HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
Cytotoxicity of the pure Z isomer against HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.
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26593399 |
体外実験
(Z)-Semaxanib ((Z)-SU5416) (10 mM; 0.25-24 h) undergoes photoisomerization in [D6]DMSO to form the E isomer and reverts to the Z isomer in the dark[1].
(Z)-Semaxanib (24 h) is cytotoxic to TAMH cells with an IC50 of 6.28 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Human pluripotent stem cell endothelial-cell differentiation
- Vascular/Branching Fractal Analysis
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Endothelial Tube Formation Assay
- Liver Cancer Modeling
- Endothelial Cell Migration/Angiogenic Sprouting Assay
- Cell Viability Determination by MTT Colorimetric Assay
化学情報
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CAS 番号 194413-58-6
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性状 Solid
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分子量 238.29
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分子式 C15H14N2O
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Color Yellow to orange
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SMILES
O=C(NC1=C/2C=CC=C1)C2=C/C3=C(C)C=C(C)N3
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別名
(Z)-SU5416
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
Br J Pharmacol
VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation. [Abstract]2026 May 5. PMID: 42083756 -
Int J Mol Sci
Curcuminoids Inhibit Angiogenic Behaviors of Human Umbilical Vein Endothelial Cells via Endoglin/Smad1 Signaling. [Abstract]2022 Mar 31;23(7):3889. PMID: 35409247 -
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (209.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Ngai MH, et al. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 05;11(1):72-80. [Content Brief]
[3]. Zhao Y, et al. Simultaneous determination of Z-SU5416 and its interconvertible geometric E-isomer in rat plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis. 2004 May 28;35(3):513-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1966 mL | 20.9828 mL | 41.9657 mL | 104.9142 mL |
| 5 mM | 0.8393 mL | 4.1966 mL | 8.3931 mL | 20.9828 mL | |
| 10 mM | 0.4197 mL | 2.0983 mL | 4.1966 mL | 10.4914 mL | |
| 15 mM | 0.2798 mL | 1.3989 mL | 2.7977 mL | 6.9943 mL | |
| 20 mM | 0.2098 mL | 1.0491 mL | 2.0983 mL | 5.2457 mL | |
| 25 mM | 0.1679 mL | 0.8393 mL | 1.6786 mL | 4.1966 mL | |
| 30 mM | 0.1399 mL | 0.6994 mL | 1.3989 mL | 3.4971 mL | |
| 40 mM | 0.1049 mL | 0.5246 mL | 1.0491 mL | 2.6229 mL | |
| 50 mM | 0.0839 mL | 0.4197 mL | 0.8393 mL | 2.0983 mL | |
| 60 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7486 mL | |
| 80 mM | 0.0525 mL | 0.2623 mL | 0.5246 mL | 1.3114 mL | |
| 100 mM | 0.0420 mL | 0.2098 mL | 0.4197 mL | 1.0491 mL |
(Z)-Semaxanib 関連分類
HY-10332 関連分類
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