KF-19418 

KF-19418 is a hair follicle stimulator with hair growth promoting activity. KF-19418 stimulates proliferation of cultured hair bulb cells from newborn mice. KF-19418 accelerates hair regrowth in hair-clipped mouse alopecia model following topical application. KF-19418 can be used for the research of alopecia^[1].

KF-19418 (0.001-10 μM; 4 days) concentration-dependently stimulates proliferation of hair bulb cells isolated from 4-day-old C3H/HeN mice, reaching ~240% of control growth at 10 μM over 4 days, while maintaining immature cell morphology and melanocyte populations^[1].
KF-19418 (3-10 μM; 3 days) promotes hair follicle elongation in cultured whole skin pieces from 4-week-old C3H mice in anagen phase, with 10 μM increasing tissue area by ~13% over 3 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KF-19418 (1% suspension; topical; daily; 2 weeks) promotes hair regrowth in a mouse alopecia model, with a hair-regrown area ratio of 38.4%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

338.36

C₂₁H₁₄N₄O

147508-06-3

O=C1C2=C(C3=C(N1C4=CC=CC=C4)N=CC=C3)NN=C2C5=CC=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shirai A, et al. KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models. J Dermatol Sci. 2001;25(3):213-218.  [Content Brief]