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Zegocractin

(Synonyms: CM-4620)
17 Cited Publications
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Based on 17 publication(s) in Google Scholar

Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.96%
  • CAS No.: 1713240-67-5
  • Formula: C19H11ClF3N3O3
  • Molecular Weight:421.76
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Zegocractin Chemical Structure
    Zegocractin Chemical Structure
  • Experimental Validation Results for Zegocractin
  • Experimental Validation Results for Zegocractin
  • Experimental Validation Results for Zegocractin
  • Experimental Validation Results for Zegocractin
  • Experimental Validation Results for Zegocractin
  • Experimental Validation Results for Zegocractin
CAS No.: 1713240-67-5
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  • Zegocractin Chemical Structure
    Zegocractin Chemical Structure
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    Zegocractin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Jan 22;45(2):116903. [Abstract]

    Customer Validation
     Schematic of drug treatment experiments. Whole blood from healthy donors (n = 3) was incubated in 6-well suspension culture plates with 5 μM sorafenib, 1 μM BVD-523, 5 μM Zegocractin (CM4620), or DMSO control for 1 h prior to being sheared for 2 h. DMSO-treated blood samples under static conditions were used as controls. PBMCs were isolated for scRNA-seq.

  • 1/16

    Zegocractin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Jan 22;45(2):116903. [Abstract]

    Customer Validation
     Feature maps of IL8 expression in classical monocytes across five conditions: static, shear stress, sorafenib + shear, BVD-523 + shear, and Zegocractin (CM4620) + shear, respectively.

  • 1/16

    Zegocractin purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Jan 22;45(2):116903. [Abstract]

    Customer Validation
     Violin plots show that BVD-523 and Zegocractin (CM4620) downregulated shear stress-induced IL8 expression in monocytes by 29.8% (adjusted p = 0.0001) and 35.4% (adjusted p = 1.16 × 10−18), respectively, as compared to DMSO sheared samples.

  • 1/16

    Zegocractin purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2024 Feb 1;22(1):92. [Abstract]

    Customer Validation
     TUNEL assay labelling dying cells (magenta) in rd1 and wild-type (wt) retinal explant cultures. DAPI (grey) was used as a nuclear counterstain. Untreated (Untr.) wt and rd1 retina were compared to retina treated with 50 µM CNGC inhibitor (L-cis diltiazem), 20 µM Zegocractin (CM4620), 40 µM NCX inhibitor (SN-6), 100 µM L-type VGCC inhibitor (D-cis diltiazem), 10 µM T-type VGCC inhibitor (TTA-A2), and 15 µM α2δ subunit VGCC ligand (DS5565). Scatter plot showing percent TUNEL-positive cells in outer nuclear layer (ONL).

  • 1/16

    Zegocractin purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2024 Feb 1;22(1):92. [Abstract]

    Customer Validation
     PAR staining (black) was performed in rd1 and wt retinal explant cultures. Untreated wt and rd1 retina were compared to drug-treated retina as in A. Untr. wt: n = 6; Untr. rd1: 17; BAPTA rd1: 7; L-cis rd1: 7; Zegocractin (CM4620) rd1: 10; SN-6 rd1: 8; D-cis rd1: 8; TTA-A2 rd1: 8; DS5565 rd1: 8; NA-184 rd1: 9.

  • 1/16

    Zegocractin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Mar 8;14(1):1286. [Abstract]

    Customer Validation
     Time courses of Ca2+ current-densities after whole-cell break-in of Orai1 A137Bpa, Orai1 L174Bpa and Orai1 A254Azi exposed to UV-light (15 s) compared to STIM1/Orai1 currents activated by passive store-depletion. After maximal activation the Orai1 channel blocker Zegocractin (CM-4620, 10 µM) was applied.

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