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Cat. No.: HY-164259

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AJM 290

AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA.

For research use only. We do not sell to patients.

CAS No.: 840474-95-5
Formula: C₂₀H₁₄FNO₄S
Molecular Weight:383.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

AJM 290 Chemical Structure

CAS No.: 840474-95-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.5 μM Compound: 8b	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 17343370]
HCT-116	IC₅₀	0.03 μM Compound: 8b	Growth inhibition of human HCT116 cells after 72 hrs by MTT assay Growth inhibition of human HCT116 cells after 72 hrs by MTT assay	[PMID: 17343370]
MRC5	EC₅₀	0.17 μM Compound: 13	Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay	[PMID: 22264753]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.016 μM Compound: 1h	Mean in vitro GI50 value against 60 human cancer cell line was determined Mean in vitro GI50 value against 60 human cancer cell line was determined	[PMID: 15658878]

Chemical Information

CAS No. 840474-95-5
Molecular Weight 383.39
Formula C₂₀H₁₄FNO₄S
SMILES

O=C1C=CC(C=C1)(C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=C(F)C=C3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Martin AR,et al. Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories. Medchemcomm. 2016 Oct 19;8(1):21-52. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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AJM 290

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AJM 290 Related Classifications

HY-164259 Related Classifications