PDCD5 - programmed cell death 5 Gene

Also Known as TFAR19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9141

About PDCD5

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:32,581,190-32,587,453 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in testis (RPKM 17.5), adrenal (RPKM 13.5) and 25 other tissues.

Summary

This gene encodes a protein that is upregulated during Apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

PDCD5 Products (1)

mRNA Protein Name
NM_004708.4 NP_004699.1 programmed cell death protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetyltransferase activator activity IDA
IDA: Inferred from direct assay
24012345 GOA
enables beta-tubulin binding IPI
IPI: Inferred from physical interaction
24375412 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
17165023 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24012345 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
24012345 GOA
involved in negative regulation of chaperone-mediated protein folding IMP
IMP: Inferred from mutant phenotype
24375412 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9920759 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24012345 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16374546 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24012345 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD5 Protein Structure

dsDNA_bind

dsDNA_bind: Double-stranded DNA-binding domain (9 - 113)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 5

  • TF-1 cell apoptosis-related protein 19

PDCD5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
Intra
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
Intra
PDCD5 O14737 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Array
32296183
Intra
PDCD5 O14737 RAD18 Homo sapiens Q9NS91
Validated Y2H
32296183
Intra
PDCD5 O14737 RAD18 Homo sapiens Q9NS91
Y2H Array
32296183
Intra
PDCD5 O14737 RAD18 Homo sapiens Q9NS91
Y2H Prey Pooling
32296183
Intra
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
PDCD5 O14737 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD5 Proteins

Cat. No. Product Name Accession Purity
HY-P71019 PDCD5 Protein, Human (His) O14737 (M1-Y125) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Fibrolamellar Carcinoma

  • Fibrolamellar Hepatocellular Carcinoma

  • Fhcc

  • Fibrolamellar Hepatocarcinoma

  • Hepatocellular Carcinoma, Fibrolamellar

  • Oncocytic Hepatocellular Tumor

  • Eosinophilic Glassy Cell Hepatoma

  • Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis

  • Fl-Hcc

  • Fibrolamellar Oncocytic Hepatoma

  • Hepatocellular Carcinoma With Increased Stromal Fibrosis

  • Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10193 PDCD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18540 Pdcd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25022 Pdcd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDCD5 MGD MGI:1913538
Rattus norvegicus PDCD5 RGD RGD:1310561
Bos taurus PDCD5 VGNC VGNC:32662
Felis catus PDCD5 VGNC VGNC:68745
Canis familiaris PDCD5 VGNC VGNC:44339
Others PDCD5 NCBI