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Cat. No.: HY-128660

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RYL-634

RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC₅₀ values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases.

For research use only. We do not sell to patients.

CAS No.: 2187352-99-2
Formula: C₂₆H₂₄F₂N₂O₂
Molecular Weight:434.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

RYL-634 Chemical Structure

CAS No.: 2187352-99-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against human Caco2 cells infected with MERS-CoV measured after 48 hrs by WST1 assay Cytotoxicity against human Caco2 cells infected with MERS-CoV measured after 48 hrs by WST1 assay	[PMID: 30938999]
HEK-293T	CC₅₀	>1.25 μM Compound: 1; RYL-634	Cytotoxicity against HEK293T cells infected with HIV pseudotyped virions assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against HEK293T cells infected with HIV pseudotyped virions assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Huh7.5.1	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Huh7.5.1	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against human Huh7.5.1 cells infected with ZIKV assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against human Huh7.5.1 cells infected with ZIKV assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Huh7.5.1	EC₅₀	>2.5 nM Compound: 1; RYL-634	Cytotoxicity against human Huh7.5.1 cells infected with DENV assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against human Huh7.5.1 cells infected with DENV assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
MDCK	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against MDCK cells infected with Gaussia tagged Influenza A virus (A/Puerto Rico/8/34(H1N1)) measured after 48 hrs by WST1 assay Cytotoxicity against MDCK cells infected with Gaussia tagged Influenza A virus (A/Puerto Rico/8/34(H1N1)) measured after 48 hrs by WST1 assay	[PMID: 30938999]
RD	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against human RD cells infected with EV71 assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against human RD cells infected with EV71 assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Vero	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against African green monkey Vero cells infected with CHIKV assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against African green monkey Vero cells infected with CHIKV assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Vero	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against African green monkey Vero cells infected with RSV assessed as decrease in cell viability after 48 hrs by WST1 assay Cytotoxicity against African green monkey Vero cells infected with RSV assessed as decrease in cell viability after 48 hrs by WST1 assay	[PMID: 30938999]
Vero	CC₅₀	>2.5 μM Compound: 1; RYL-634	Cytotoxicity against African green monkey Vero cells infected with SFTSV measured after 48 hrs by WST1 assay Cytotoxicity against African green monkey Vero cells infected with SFTSV measured after 48 hrs by WST1 assay	[PMID: 30938999]
Vero	EC₅₀	260 nM Compound: 1; RYL-634	Antiviral activity against CHIKV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 36 hrs post infection Antiviral activity against CHIKV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 36 hrs post infection	[PMID: 30938999]
Vero	EC₅₀	300 nM Compound: 1; RYL-634	Antiviral activity against SFTSV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 4 days post infection Antiviral activity against SFTSV infected in African green monkey Vero cells assessed as reduction in viral titre measured at 4 days post infection	[PMID: 30938999]
Vero	EC₅₀	60 nM Compound: 1; RYL-634	Antiviral activity against RSV infected in African green monkey Vero cells assessed as inhibition of viral replication measured after 5 to 7 days by plaque formation assay Antiviral activity against RSV infected in African green monkey Vero cells assessed as inhibition of viral replication measured after 5 to 7 days by plaque formation assay	[PMID: 30938999]

Chemical Information

CAS No. 2187352-99-2
Molecular Weight 434.48
Formula C₂₆H₂₄F₂N₂O₂
SMILES

O=C1C(C)=C(C2=CC(F)=C(OC3=CC=C(N(CC)CC)C=C3)C=C2)NC4=CC=CC(F)=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors. J Med Chem. 2019 Apr 25;62(8):4056-4073. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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