2MD
2MD is an orally active vitamin D analog. 2MD stimulates periosteal bone formation and decreases trabecular bone resorption. Thus 2MD restores trabecular and cortical bone mass and strength. 2MD also regulates intraocular pressure (IOP)-relative genes and reduces IOP in non-human primates.
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- CAS No.: 213250-70-5
- 화학식: C27H44O3
- 분자량:416.64
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | ED50 |
0.08 nM
Compound: 2, 2MD
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Induction of human HL60 cell differentiation after 4 days by NBT reduction assay
Induction of human HL60 cell differentiation after 4 days by NBT reduction assay
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[PMID: 22490010] |
| HL-60 | ED50 |
1.5 x 10-10M
Compound: 6b
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Induced differentiation of human promyelocyte HL-60 cells into monocytes
Induced differentiation of human promyelocyte HL-60 cells into monocytes
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[PMID: 9804706] |
2MD (0.5-10 ng/kg, 0,1 mL/day; p.o.; once daily for 16 weeks) not only restores both trabecular and cortical bone mass, but also increases bone mass and strength in osteopenic ovariectomized (OVX) rats by stimulating bone formation on the periosteal surface and decreasing bone resorption on the trabecular surface in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized (OVX) rats model (Sprague-Dawley female rats; 4-month-old)[2]
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Dosage:0.5, 1, 2.5, 5, and 10 ng/kg, 0,1 mL/day
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Administration:Oral gavage; once daily for 16 weeks
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Result:Significantly increased serum calcium at 2.5, 5, or 10 ng/kg/day.
Dose-dependent reduction in osteoclast number and trabecular osteoclast surface, and dose-dependent increased in periosteal bone formation.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 213250-70-5
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분자량 416.64
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화학식 C27H44O3
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@@H](C)CCCC(C)(O)C)([H])/C(CCC1)=C/C=C3C[C@H](C([C@@H](C\3)O)=C)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Kutuzova GD, et al. 1α,25-Dihydroxyvitamin D(3) and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D(3) (2MD), suppress intraocular pressure in non-human primates. Arch Biochem Biophys. 2012 Feb 1;518(1):53-60. [Content Brief]
[2]. Ke HZ, et al. A new vitamin D analog, 2MD, restores trabecular and cortical bone mass and strength in ovariectomized rats with established osteopenia. J Bone Miner Res. 2005 Oct;20(10):1742-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2MD Related Classifications
HY-148698 Related Classifications
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