7ß,27-Dihydroxycholesterol
Based on 1 Customer Validation
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1.
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- Purity: 99.58%
- CAS No.: 240129-43-5
- 화학식: C27H46O3
- 분자량:418.65
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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RORγt 120 nM (Ki) |
Chemical Information
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CAS No. 240129-43-5
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Appearance Solid
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분자량 418.65
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화학식 C27H46O3
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Color White to off-white
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SMILES
C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
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Synonyms
7β, 27-OHC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
Ethanol : ≥ 20 mg/mL (47.77 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.3886 mL | 11.9432 mL | 23.8863 mL | 59.7158 mL |
| 5 mM | 0.4777 mL | 2.3886 mL | 4.7773 mL | 11.9432 mL | |
| 10 mM | 0.2389 mL | 1.1943 mL | 2.3886 mL | 5.9716 mL | |
| 15 mM | 0.1592 mL | 0.7962 mL | 1.5924 mL | 3.9811 mL | |
| 20 mM | 0.1194 mL | 0.5972 mL | 1.1943 mL | 2.9858 mL | |
| 25 mM | 0.0955 mL | 0.4777 mL | 0.9555 mL | 2.3886 mL | |
| 30 mM | 0.0796 mL | 0.3981 mL | 0.7962 mL | 1.9905 mL | |
| 40 mM | 0.0597 mL | 0.2986 mL | 0.5972 mL | 1.4929 mL |
7ß,27-Dihydroxycholesterol Related Classifications
HY-138115 Related Classifications
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