Cat. No.: HY-113298

Citraconic acid

(Synonyms: Methylmaleic acid)

6 Cited Publications

고객리뷰

Based on 6 publication(s) in Google Scholar

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.08%
CAS No.: 498-23-7
화학식: C₅H₆O₄
분자량:130.10

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Citraconic acid Chemical Structure

CAS No.: 498-23-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

NLRP3

All NOD-like Receptor (NLR) Isoforms :

In Vitro

Hydrogel preparation and enzyme immobilization experiments:
Citraconic acid (molar ratio of acrylamide to 1:3; polymerization reaction time 24 h) can be used to prepare chitosan-polyacrylamide-citraconic acid semi-IPN hydrogels and significantly improve the hydrogel swelling rate (240%-400%). The yield of lipase immobilization in the encapsulation method is high^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Citraconic acid (50 mg/kg; intraperitoneal injection; once a day; 3 days) significantly reduces the levels of serum creatinine (Cr), urea (Urea) and cystatin C (Cys-C) in the rat renal ischemia-reperfusion injury model, alleviates renal tubular epithelial cell damage, inflammatory cell infiltration and oxidative stress, and inhibits NLRP3 inflammasome activation and IL-1β and IL-18 release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rat renal ischemia-reperfusion injury model (250-300 g，8-10 weeks old)^[1]
Dosage:

50 mg/kg
Administration:

Intraperitoneal injection, once daily for 3 consecutive days, starting 3 days before ischemia-reperfusion surgery
Result:

Significantly improved renal function compared to the ischemia-reperfusion (IRI) group.
Decreased Serum Cr from 1.82 ± 0.23 mg/dL (IRI) to 1.25 ± 0.18 mg/dL, urea from 72.3 mg/dL to 51.6 mg/dL, and Cys-C from 1.57 ± 0.19.

Chemical Information

CAS No. 498-23-7
Appearance Solid
분자량 130.10
화학식 C₅H₆O₄
Color White to off-white
SMILES

O=C(O)/C(C)=C\C(O)=O
Synonyms

Methylmaleic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (6)

All

Sort by:

Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Host Microbe

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation. [Abstract]

2025 Sep 30:S1931-3128(25)00375-0. PMID: 41033313
Sci Immunol

Citraconate preserves T cell stemness and antitumor immunity. [Abstract]

2026 May;11(119):eadz0348. PMID: 42066062
Cell Rep

4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1. [Abstract]

2026 Mar 30;45(4):117179. PMID: 41915469
Cell Rep

4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING. [Abstract]

2023 Feb 28;42(3):112145. PMID: 36862550
Food Funct

Sulfated polysaccharides from sea cucumber mitigate acetaminophen-induced acute liver injury in mice via citraconic acid-mediated inhibition of oxidative stress. [Abstract]

2026 Jan 26;17(2):1074-1092. PMID: 41527470

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (768.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (768.64 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

7.6864 mL

38.4320 mL

76.8639 mL

5 mM

1.5373 mL

7.6864 mL

15.3728 mL

10 mM

0.7686 mL

3.8432 mL

7.6864 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (19.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (19.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (19.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang B, et al. Evaluation of the efficacy of rat renal ischemia-reperfusion injury after itaconic acid and its isomers treatment by contrast-enhanced ultrasound (CEUS). 2024.

[2]. Strelko CL, et al. Itaconic acid is a mammalian metabolite induced during macrophage activation. J Am Chem Soc. 2011 Oct 19;133(41):16386-9. [Content Brief]

[3]. Pulat M, et al. Lipase release through semi-interpenetrating polymer network hydrogels based on chitosan, acrylamide, and citraconic acid. Artif Cells Nanomed Biotechnol. 2014 Apr;42(2):121-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	7.6864 mL	38.4320 mL	76.8639 mL	192.1599 mL
	5 mM	1.5373 mL	7.6864 mL	15.3728 mL	38.4320 mL
	10 mM	0.7686 mL	3.8432 mL	7.6864 mL	19.2160 mL
	15 mM	0.5124 mL	2.5621 mL	5.1243 mL	12.8107 mL
	20 mM	0.3843 mL	1.9216 mL	3.8432 mL	9.6080 mL
	25 mM	0.3075 mL	1.5373 mL	3.0746 mL	7.6864 mL
	30 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	40 mM	0.1922 mL	0.9608 mL	1.9216 mL	4.8040 mL
	50 mM	0.1537 mL	0.7686 mL	1.5373 mL	3.8432 mL
	60 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	80 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4020 mL
	100 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9216 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Citraconic acid

6 Cited Publications

100 mg 견적 받기

Subscribe to the

MedChemExpress

Newsletter

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Citraconic acid

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Aging Compound Library

Antioxidant Compound Library

Lipid Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Anti-Cancer Metabolism Compound Library

Microbial Metabolite Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Food-Sourced Compound Library

Anti-Colorectal Cancer Compound Library

Antidepressant Compound Library

Human Metabolite Library

Pain-Related Compound Library

Metabolic Enzyme Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Anti-Ovarian Cancer Compound Library

Inflammasomes related Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Fatty Acids Compound Library

Anti-Fibrosis Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Amino Acid Metabolite Compound Library

Pattern Recognition Receptors Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Carbohydrate Metabolite Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Citraconic acid

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

Publications (6)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Citraconic acid Related Classifications

HY-113298 Related Classifications