TMPRSS6
Matriptase-2; Transmembrane protease serine 6
TMPRSS6 (Matriptase-2) is a serine protease highly expressed in the liver. TMPRSS6 functions as a negative regulator of the expression of the systemic iron-regulatory hormone hepcidin.
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TMPRSS6 관련 제품 (7)
관련 제품 (7)
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Sapablursen
0 ImagesCat. No.: HY-177662CAS No.: 2273007-95-5Synonyms: IONIS-TMPRSS6-Lrx; ISIS 702843
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Manusiran sodium scrambled negative control
0 ImagesCat. No.: HY-147278CManusiran sodium scrambled negative control is the sequence scrambled negative control of Manusiran sodium.
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SARSi-4 sodium scrambled negative control
0 ImagesCat. No.: HY-177663ASARSi-4 sodium scrambled negative control is the sequence scrambled negative control of SARSi-4 sodium.
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Sapablursen sodium
0 ImagesCat. No.: HY-177662ACAS No.: 2273008-00-5Synonyms: IONIS-TMPRSS6-Lrx sodium; ISIS 702843 sodium
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Manusiran sodium
0 ImagesCat. No.: HY-147278ASynonyms: Divesiran sodium; SLN124 sodiumManusiran sodium (Divesiran sodium) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran sodium increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran sodium with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran sodium can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia.
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Manusiran
0 ImagesCat. No.: HY-147278CAS No.: 2646704-10-9Synonyms: Divesiran; SLN124Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia.
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WGU55
0 ImagesCat. No.: HY-180217WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis.
