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Cat. No.: HY-156409

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ABBV-712

Name: ABBV-712
Brand: MedChemExpress
SKU: HY-156409
Price: 370.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

ABBV-712 is a selective and orally active inhibitor of Tyrosine kinase 2 (TYK2). ABBV-712 has EC₅₀ values of 0.01, 0.19, and 0.17 μM for TYK2 JH2, TYK2 cells and human whole blood, respectively. ABBV-712 has anti-inflammatory activity and can be used in the research of autoimmune diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.94%
CAS No.: 2368945-27-9
화학식: C₂₄H₂₈N₄O₅
분자량:452.50

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ABBV-712 Chemical Structure

CAS No.: 2368945-27-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All JAK Isoforms :

In Vivo

ABBV-712 (100 mg/kg; oral administration; BID/QD; 5 days) has a protective effect in the mouse ear dermatitis model and can reduce the ear thickness of mice^[1].
ABBV-712 (10-600 mg/kg; oral administration; single dose) can inhibit the production of IFN-γ in a dose-dependent manner in mice stimulated with IL-12/IL-18^[1].
Pharmacokinetic Analysis in Rats^[1]

Route	Dose (mg/kg)	CLb,u (L/h/kg)	T_1/2 (h)	V_SS (L/kg)	F (%)
p.o. and i.v.	1	4.1	0.6	1.9	19

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2368945-27-9
Appearance Solid
분자량 452.50
화학식 C₂₄H₂₈N₄O₅
Color Off-white to light yellow
SMILES

CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 250 mg/mL (552.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2099 mL

11.0497 mL

22.0994 mL

5 mM

0.4420 mL

2.2099 mL

4.4199 mL

10 mM

0.2210 mL

1.1050 mL

2.2099 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Eric Breinlinger, et al. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J Med Chem. 2023 Oct 26;66(20):14335-14356. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2099 mL	11.0497 mL	22.0994 mL	55.2486 mL
	5 mM	0.4420 mL	2.2099 mL	4.4199 mL	11.0497 mL
	10 mM	0.2210 mL	1.1050 mL	2.2099 mL	5.5249 mL
	15 mM	0.1473 mL	0.7366 mL	1.4733 mL	3.6832 mL
	20 mM	0.1105 mL	0.5525 mL	1.1050 mL	2.7624 mL
	25 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2099 mL
	30 mM	0.0737 mL	0.3683 mL	0.7366 mL	1.8416 mL
	40 mM	0.0552 mL	0.2762 mL	0.5525 mL	1.3812 mL
	50 mM	0.0442 mL	0.2210 mL	0.4420 mL	1.1050 mL
	60 mM	0.0368 mL	0.1842 mL	0.3683 mL	0.9208 mL
	80 mM	0.0276 mL	0.1381 mL	0.2762 mL	0.6906 mL
	100 mM	0.0221 mL	0.1105 mL	0.2210 mL	0.5525 mL

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ABBV-712

All JAK Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ABBV-712 Related Classifications

HY-156409 Related Classifications

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