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Cat. No.: HY-109047

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Adafosbuvir

Name: Adafosbuvir
Brand: MedChemExpress
SKU: HY-109047
Availability: PreOrder

(Synonyms: AL-335)

Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase.

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CAS No.: 1613589-09-5
화학식: C₂₂H₂₉FN₃O₁₀P
분자량:545.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Adafosbuvir Chemical Structure

CAS No.: 1613589-09-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 53; AL-335	Cytotoxicity against human A549 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human A549 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]
HeLa	CC₅₀	>100 μM Compound: 53; AL-335	Cytotoxicity against human HeLa cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human HeLa cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]
HepG2	CC₅₀	>50 μM Compound: 35	Cytotoxicity against human HepG2 cells after 96 hrs by CCK-8 assay Cytotoxicity against human HepG2 cells after 96 hrs by CCK-8 assay	[PMID: 29801997]
HepG2	CC₅₀	>100 μM Compound: 53; AL-335	Cytotoxicity against human HepG2 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human HepG2 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]
Huh-7	CC₅₀	96.1 μM Compound: 53; AL-335	Cytotoxicity against human HuH7 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human HuH7 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]
MT4	CC₅₀	>100 μM Compound: 53; AL-335	Cytotoxicity against human MT4 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human MT4 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]
U-937	CC₅₀	>100 μM Compound: 53; AL-335	Cytotoxicity against human U937 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay Cytotoxicity against human U937 cells treated for 8 days measured post-last dose by Celltiter-glo luminescent assay	[PMID: 30951311]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1613589-09-5
분자량 545.45
화학식 C₂₂H₂₉FN₃O₁₀P
SMILES

C[C@@]1([C@H](N(C=CC2=O)C(N2)=O)O[C@@](COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)(F)[C@H]1O)O
Synonyms

AL-335
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tetsuo Takehara, et al. JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study. J Gastroenterol. 2020 Jun;55(6):640-652. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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