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Cat. No.: HY-164259

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AJM 290

AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 840474-95-5
화학식: C₂₀H₁₄FNO₄S
분자량:383.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

AJM 290 Chemical Structure

CAS No.: 840474-95-5

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.5 μM Compound: 8b	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 17343370]
HCT-116	IC₅₀	0.03 μM Compound: 8b	Growth inhibition of human HCT116 cells after 72 hrs by MTT assay Growth inhibition of human HCT116 cells after 72 hrs by MTT assay	[PMID: 17343370]
MRC5	EC₅₀	0.17 μM Compound: 13	Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay	[PMID: 22264753]
Panel NCI-60 (60 carcinoma cell lines)	GI₅₀	0.016 μM Compound: 1h	Mean in vitro GI50 value against 60 human cancer cell line was determined Mean in vitro GI50 value against 60 human cancer cell line was determined	[PMID: 15658878]

Chemical Information

CAS No. 840474-95-5
분자량 383.39
화학식 C₂₀H₁₄FNO₄S
SMILES

O=C1C=CC(C=C1)(C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=C(F)C=C3)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Martin AR,et al. Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories. Medchemcomm. 2016 Oct 19;8(1):21-52. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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CAS No.:
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Purity:
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AJM 290

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AJM 290 Related Classifications

HY-164259 Related Classifications