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Cat. No.: HY-119951

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AKI-001

AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC₅₀ of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes.

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CAS No.: 925218-37-7
화학식: C₂₁H₂₄N₄O
분자량:348.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AKI-001 Chemical Structure

CAS No.: 925218-37-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Aurora Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.07 μM Compound: 32, AKI-001	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 18630890]
HT-29	IC₅₀	0.07 μM Compound: 32, AKI-001	Antiproliferative activity against human HT29 cells Antiproliferative activity against human HT29 cells	[PMID: 18630890]
MCF7	IC₅₀	0.1 μM Compound: 32, AKI-001	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 18630890]
MOLT-4	IC₅₀	0.11 μM Compound: 32, AKI-001	Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs	[PMID: 18630890]

Chemical Information

CAS No. 925218-37-7
분자량 348.44
화학식 C₂₁H₂₄N₄O
SMILES

O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rawson, T. E., et al., (2008). A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51(15), 4465-4475. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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AKI-001

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AKI-001 Related Classifications

HY-119951 Related Classifications