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Cat. No.: HY-107420S

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AY 9944-d₈

AY 9944-d₈ is the deuterium labeled AY 9944 (HY-107420). AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC₅₀ of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₂H₂₂D₈Cl₄N₂
분자량:472.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY 9944-d₈ Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- 신청
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Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 366-93-8
분자량 472.35
화학식 C₂₂H₂₂D₈Cl₄N₂
SMILES

ClC(C([2H])=C([2H])C([2H])=C1[2H])=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C([2H])=C([2H])C([2H])=C3[2H])Cl.Cl.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.