Bempedoic acid-d4
Based on 1 Customer Validation
Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
- CAS No.: 2408131-70-2
- 화학식: C19H32D4O5
- 분자량:348.51
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2408131-70-2
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Unlabeled Cas 738606-46-7
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Appearance Solid
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분자량 348.51
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화학식 C19H32D4O5
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Color White to off-white
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SMILES
OC(C(C)(C)CCCCC([2H])([2H])C(O)C([2H])([2H])CCCCC(C)(C)C(O)=O)=O
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Synonyms
ETC-1002-d4; ESP-55016-d4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (143.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pinkosky SL, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013 Jan;54(1):134-51. [Content Brief]
[2]. Filippov S, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013 Aug;54(8):2095-108. [Content Brief]
[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8694 mL | 14.3468 mL | 28.6936 mL | 71.7340 mL |
| 5 mM | 0.5739 mL | 2.8694 mL | 5.7387 mL | 14.3468 mL | |
| 10 mM | 0.2869 mL | 1.4347 mL | 2.8694 mL | 7.1734 mL | |
| 15 mM | 0.1913 mL | 0.9565 mL | 1.9129 mL | 4.7823 mL | |
| 20 mM | 0.1435 mL | 0.7173 mL | 1.4347 mL | 3.5867 mL | |
| 25 mM | 0.1148 mL | 0.5739 mL | 1.1477 mL | 2.8694 mL | |
| 30 mM | 0.0956 mL | 0.4782 mL | 0.9565 mL | 2.3911 mL | |
| 40 mM | 0.0717 mL | 0.3587 mL | 0.7173 mL | 1.7933 mL | |
| 50 mM | 0.0574 mL | 0.2869 mL | 0.5739 mL | 1.4347 mL | |
| 60 mM | 0.0478 mL | 0.2391 mL | 0.4782 mL | 1.1956 mL | |
| 80 mM | 0.0359 mL | 0.1793 mL | 0.3587 mL | 0.8967 mL | |
| 100 mM | 0.0287 mL | 0.1435 mL | 0.2869 mL | 0.7173 mL |
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