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Cat. No.: HY-115516

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BI-1388

BI-1388 is a macrocyclic acylsulfonamide-based HCV NS3-4A protease inhibitor. BI-1388 inhibits clinically relevant drug-resistant mutant strains (KRAS^D168V gt 1b and KRAS^R155K gt 1a) and exhibits high liver distribution. BI-1388 is applicable for the research of HCV infection.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

The BI-1388 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.

CAS No.: 1309952-03-1
화학식: C₄₁H₅₃N₇O₉S
분자량:819.97

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BI-1388 Chemical Structure

CAS No.: 1309952-03-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

K-RAS

All Ras Isoforms :

In Vitro

BI-1388 (compound 19) inhibits the replication of HCV genotype 1b D168V variant, with an EC₅₀ of 1.0 nM at 72 h; it also inhibits the replication of HCV genotype 1a R155K variant, with an EC₅₀ of 0.14 nM at 72 h^[1].
The half-life of BI-1388 in human liver microsomes is 54 min^[1].
The half-life of BI-1388 in rat liver microsomes is 138 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC	T_1/2	V_ss	CL	Bioavailability
Rat^[1]	10 mg/kg	p.o.	1.3 μM	1.4 μM·h	/	/	/	/
Rat^[1]	4 mg/kg	i.v.	/	/	2.6 h	0.97 L/kg	19 mL/min/kg	14 %

Chemical Information

CAS No. 1309952-03-1
분자량 819.97
화학식 C₄₁H₅₃N₇O₉S
SMILES

O=C([C@]([C@]1([H])/C=C\CCCCC[C@@H]2NC(C3=NN(C)C=C3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(OC(C)C)=NC5=C(C)C(OC)=CC=C45)C6)([H])N6C2=O)=O)NS(=O)(C7(C)CC7)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Moreau B, et al. Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution. J Med Chem. 2014;57(5):1770-1776. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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BI-1388

All Ras Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BI-1388 Related Classifications

HY-115516 Related Classifications