BILA 1906 BS
BILA 1906 BS is a HIV protease inhibitor. BILA 1906 BS prevents HIV-1 replication via inhibition of viral protease-mediated cleavage of Gag and Gag-Pol polyprotein precursors during virion maturation. BILA 1906 BS blocks maturation of p24 proteins in wild-type HIV-1, impairing polyprotein processing and viral maturation. BILA 1906 BS can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.
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- CAS No.: 154612-31-4
- 화학식: C41H52N6O4S
- 분자량:724.95
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
BILA 1906 BS (serial twofold dilutions; 3 days) inhibits wild-type HIV-1 replication in acutely infected C8166 T cells with an EC50 of 1 nM[1].
BILA 1906 BS inhibits wild-type HIV-1 protease with a Ki of 1.7 pM, and protease mutations selected by BILA 1906 BS reduce inhibitor binding, with the HIV-1V32I M46I A71V I84A mutant showing a 12,000-fold increase in Ki[1].
BILA 1906 BS (0-1000 nM; 3 days) blocks polyprotein processing in wild-type HIV-1 particles from transfected 293 cells, but has minimal effect on processing in highly resistant HIV-1 clones bearing protease mutations V32I, M46I, A71V, I84A and a p1/p6 cleavage site mutation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:293 cells (transfected with HIV-1 molecular clones)
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Concentration:0, 10, 100, 1000 nM
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Incubation Time:3 days post-transfection
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Result:Blocked complete p24 production in wild-type HIV-1 particles at 100 nM.
Blocked Pr55gag and Pr160gag-pol processing in wild-type HIV-1 particles at 1 μM.
Showed almost no effect on Gag processing in highly resistant clone 32/46/71/84A at 1 μM, with only a slight appearance of a 49-kDa intermediate at 100 nM and 1 μM.
Chemical Information
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CAS No. 154612-31-4
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분자량 724.95
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화학식 C41H52N6O4S
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SMILES
O=C(N[C@@H](C(C)C)C(N[C@H]([C@@H](CN1[C@@H](C[C@@H](CC1)SCC2=CC=CN=C2)C(NC(C)(C)C)=O)O)CC3=CC=CC=C3)=O)C4=NC5=CC=CC=C5C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BILA 1906 BS Related Classifications
HY-126120 Related Classifications
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