Calcium gluconate
Based on 1 Customer Validation
Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.
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- Purity: 99.86%
- CAS No.: 299-28-5
- 화학식: C6H12O7.1/2Ca
- 분자량:216.20
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Calcium gluconate (12.5-50 mg/kg; i.p.; single dose) dose-dependently inhibits LPS-induced acute lung injury in male C57BL/6J mice, with the 50 mg/kg dose producing the most significant reductions in histopathological injury, neutrophil influx, pro-inflammatory cytokine release, and ERK phosphorylation[3].
Calcium gluconate (50 mg/kg; i.p.; single dose) does not induce measurable inflammatory changes in healthy male C57BL/6J mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Atp4b-deficient (Atp4b−/−)[2]
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Dosage:1%
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Administration:p.o.; daily; 4 weeks
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Result:Maintained serum parathyroid hormone (PTH) levels within normal ranges, matching control mice levels.
Maintained C-terminal telopeptide (CTX) levels within normal ranges, matching control mice levels.
Kept osteoclast numbers per bone perimeter (OcN/BPm) within normal ranges, equivalent to control mice levels.
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Animal Model:C57BL/6J (male, 4-6 weeks old, LPS-induced ALI)[3]
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Dosage:12.5 mg/kg; 25 mg/kg; 50 mg/kg
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Administration:i.p.; single dose
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Result:Significantly reduced LPS-induced ALI histopathological scores compared to the LPS-only group, with the highest reduction observed at the 50 mg/kg dose.
Significantly reduced LPS-induced neutrophil influx into BALF at 25 mg/kg and 50 mg/kg; the 12.5 mg/kg dose did not produce a significant reduction.
Did not significantly reduce BALF IL-1β levels at 12.5 mg/kg; significantly reduced BALF IL-1β levels at 25 mg/kg and 50 mg/kg.
Did not significantly reduce BALF IL-6 levels at 12.5 mg/kg; significantly reduced BALF IL-6 levels at 25 mg/kg and 50 mg/kg.
Significantly reduced BALF TNF-α levels at 12.5 mg/kg and 25 mg/kg; produced a more significant reduction at 50 mg/kg.
Significantly reduced LPS-induced increases in lung tissue p-ERK expression at 12.5 mg/kg; produced greater, more significant reductions at 25 mg/kg and 50 mg/kg.
Chemical Information
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CAS No. 299-28-5
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Appearance Solid
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분자량 216.20
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화학식 C6H12O7.1/2Ca
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Color White to off-white
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SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.[Ca].[1/2]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : 25 mg/mL (115.63 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shrivastava OP, et al. Calcium gluconate pretreatment for prevention of succinylcholine-induced myalgia. Anesth Analg. 1983;62(1):59-62. [Content Brief]
[2]. Krause M, et al. Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int. 2015;26(3):987-995. [Content Brief]
[3]. Liu L, et al. Effects of calcium gluconate on lipopolysaccharide-induced acute lung injury in mice. Biochem Biophys Res Commun. 2018;503(4):2931-2935. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6253 mL | 23.1267 mL | 46.2535 mL | 115.6337 mL |
| 5 mM | 0.9251 mL | 4.6253 mL | 9.2507 mL | 23.1267 mL | |
| 10 mM | 0.4625 mL | 2.3127 mL | 4.6253 mL | 11.5634 mL | |
| 15 mM | 0.3084 mL | 1.5418 mL | 3.0836 mL | 7.7089 mL | |
| 20 mM | 0.2313 mL | 1.1563 mL | 2.3127 mL | 5.7817 mL | |
| 25 mM | 0.1850 mL | 0.9251 mL | 1.8501 mL | 4.6253 mL | |
| 30 mM | 0.1542 mL | 0.7709 mL | 1.5418 mL | 3.8545 mL | |
| 40 mM | 0.1156 mL | 0.5782 mL | 1.1563 mL | 2.8908 mL | |
| 50 mM | 0.0925 mL | 0.4625 mL | 0.9251 mL | 2.3127 mL | |
| 60 mM | 0.0771 mL | 0.3854 mL | 0.7709 mL | 1.9272 mL | |
| 80 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4454 mL | |
| 100 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL | 1.1563 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Calcium gluconate Related Classifications
HY-W145486 Related Classifications
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