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Cat. No.: HY-135451

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CFM 1571

CFM 1571 is a soluble guanylyl cyclase (sGC) activator with an IC₅₀ of ~5.5 μM. CFM 1571 activates sGC in a NO-independent manner and exerts a synergistic effect with NO. CFM 1571 inhibits platelet aggregation.

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CAS No.: 268725-86-6
화학식: C₂₃H₂₈N₄O₃
분자량:408.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CFM 1571 Chemical Structure

CAS No.: 268725-86-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
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Calculators
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Biological Activity

제품 설명

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	EC₅₀	5.49 μM Compound: 32	Activation of bovine sGC Enzyme (soluble Guanylate Cyclase) in Sf21 cells infected with baculo virus in the presence of 30 nM of PAPA/NO Activation of bovine sGC Enzyme (soluble Guanylate Cyclase) in Sf21 cells infected with baculo virus in the presence of 30 nM of PAPA/NO	[PMID: 11141091]

In Vitro

CFM 1571 is a haem-dependent sGC stimulator that weakly activates purified sGC alone, strongly synergizes with NO, inhibits collagen-induced washed platelet aggregation with an IC₅₀ of 2.8 μM, and has ~12% bioavailability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 268725-86-6
분자량 408.49
화학식 C₂₃H₂₈N₄O₃
SMILES

O=C(C1=CC(OCCCN(C)C)=NN1CC2=CC=CC=C2)NC3=CC=C(C=C3)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Evgenov OV, et al. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006 Sep;5(9):755-68. [Content Brief]

[2]. Jackson EB Jr, et al. Pharmacologic modulators of soluble guanylate cyclase/cyclic guanosine monophosphate in the vascular system - from bench top to bedside. Curr Vasc Pharmacol. 2007;5(1):1-14. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
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CFM 1571

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CFM 1571 Related Classifications

HY-135451 Related Classifications