CP-447697
Based on 1 Customer Validation
CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.70%
- CAS No.: 1092847-21-6
- 화학식: C29H26ClF2N3O2S
- 분자량:554.05
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 31 nM (C5a receptor)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
250 nM
Compound: 2, CP-447697
|
Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
Inhibition of C5a-induced elastase release in human neutrophils measured by cleavage of chromogenic MeO-Suc-Ala-Ala-ProlVal-pNA
|
[PMID: 18809326] |
| U-937 | IC50 |
31 nM
Compound: 2, CP-447697
|
Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
Displacement of [125I]r-hC5a from C5a receptor in cAMP differentiated human U937 cells
|
[PMID: 18809326] |
Chemical Information
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CAS No. 1092847-21-6
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Appearance Solid
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분자량 554.05
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화학식 C29H26ClF2N3O2S
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Color White to off-white
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SMILES
ClC(C=C1)=CC=C1CCN(C(C2=CSC3=C2C=CC=C3)=O)C4CCN(C(NC5=CC=C(F)C=C5F)=O)CC4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 125 mg/mL (225.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8049 mL | 9.0245 mL | 18.0489 mL | 45.1223 mL |
| 5 mM | 0.3610 mL | 1.8049 mL | 3.6098 mL | 9.0245 mL | |
| 10 mM | 0.1805 mL | 0.9024 mL | 1.8049 mL | 4.5122 mL | |
| 15 mM | 0.1203 mL | 0.6016 mL | 1.2033 mL | 3.0082 mL | |
| 20 mM | 0.0902 mL | 0.4512 mL | 0.9024 mL | 2.2561 mL | |
| 25 mM | 0.0722 mL | 0.3610 mL | 0.7220 mL | 1.8049 mL | |
| 30 mM | 0.0602 mL | 0.3008 mL | 0.6016 mL | 1.5041 mL | |
| 40 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1281 mL | |
| 50 mM | 0.0361 mL | 0.1805 mL | 0.3610 mL | 0.9024 mL | |
| 60 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.7520 mL | |
| 80 mM | 0.0226 mL | 0.1128 mL | 0.2256 mL | 0.5640 mL | |
| 100 mM | 0.0180 mL | 0.0902 mL | 0.1805 mL | 0.4512 mL |
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