For-Met-OH
Based on 1 publication(s) in Google Scholar
For-Met-OH (N-Formylmethionine) can be involved in the translation process of bacteria, chloroplasts, and mitochondria. For-Met-OH plays different roles in different species and organelles, such as promoting the formation of protein complexes in mitochondria and acting as a degradation signal in bacteria and yeast. The level of For-Met-OH is closely related to certain diseases, for example, For-Met-OH is a potential biomarker for metabolic disorders and poor prognosis in critically ill patients.
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- Purity: 99.70%
- CAS No.: 4289-98-9
- 화학식: C6H11NO3S
- 분자량:177.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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For-Met-OH (Standard)
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Publications Citing Use of MedChemExpress (MCE) For-Met-OH
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
For-Met-OH is crucial for the growth and infection of Listeria monocytogenes, and strains deficient in For-Met-OH show significantly impaired growth ability in broth medium and macrophages[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4289-98-9
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Appearance Solid
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분자량 177.22
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화학식 C6H11NO3S
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Color White to off-white
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SMILES
CSCC[C@@H](C(O)=O)NC=O
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Synonyms
N-Formylmethionine
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
An inulin-based fiber-rich diet alleviates doxorubicin cardiotoxicity via the fMet-KCNE2 axis to attenuate ferroptosis and oxidative stress. [Abstract]2026 Jun 17:254:211-226. PMID: 42309360
용액&용해도
DMSO : 100 mg/mL (564.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (282.14 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (35.27 mM); Clear solution
This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.11 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Lee CS, et al. Where Does N-Formylmethionine Come from? What for? Where Is It Going? What is the origin of N-formylmethionine in eukaryotic cells? Mol Cells. 2022 Mar 31;45(3):109-111. [Content Brief]
[2]. Sigurdsson MI, et al. Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study. Crit Care. 2022 Oct 19;26(1):321. [Content Brief]
[3]. Feng Y, et al. The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine. mBio. 2023 Oct 31;14(5):e0107423. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.6427 mL | 28.2135 mL | 56.4270 mL | 141.0676 mL |
| 5 mM | 1.1285 mL | 5.6427 mL | 11.2854 mL | 28.2135 mL | |
| 10 mM | 0.5643 mL | 2.8214 mL | 5.6427 mL | 14.1068 mL | |
| 15 mM | 0.3762 mL | 1.8809 mL | 3.7618 mL | 9.4045 mL | |
| 20 mM | 0.2821 mL | 1.4107 mL | 2.8214 mL | 7.0534 mL | |
| 25 mM | 0.2257 mL | 1.1285 mL | 2.2571 mL | 5.6427 mL | |
| 30 mM | 0.1881 mL | 0.9405 mL | 1.8809 mL | 4.7023 mL | |
| 40 mM | 0.1411 mL | 0.7053 mL | 1.4107 mL | 3.5267 mL | |
| 50 mM | 0.1129 mL | 0.5643 mL | 1.1285 mL | 2.8214 mL | |
| 60 mM | 0.0940 mL | 0.4702 mL | 0.9405 mL | 2.3511 mL | |
| 80 mM | 0.0705 mL | 0.3527 mL | 0.7053 mL | 1.7633 mL | |
| 100 mM | 0.0564 mL | 0.2821 mL | 0.5643 mL | 1.4107 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
For-Met-OH Related Classifications
HY-W016647 Related Classifications
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