CAPN6 - calpain 6 Gene

Also Known as CANPX; CAPNX; CalpM; DJ914P14.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 827

About CAPN6

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,245,099-111,270,483 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 20 paralogues. Biased expression in placenta (RPKM 59.5), endometrium (RPKM 13.7) and 5 other tissues.

Summary

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of Other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting Apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

CAPN6 Products (1)

mRNA	Protein	Name
NM_014289.4	NP_055104.2	calpain-6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17210638	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	17210638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPN6 Protein Structure

Peptidase_C2

Calpain_III

C2

0
100
200
300
400
500
600
641 a.a.

Protein Preferred Names	Protein Names
calpain-6	calpain-like protease X-linked

CAPN6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAPN6	Q9Y6Q1	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	CAPN6	Q9Y6Q1	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CAPN6 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P89990	Calpain 6 Antibody (YA9334)	WB, IP, FC	human

Related Diseases

Diseases	Alias
Leiomyosarcoma	Leiomyosarcomas
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Corneal Dystrophy, Endothelial, X-Linked	X-Linked Endothelial Corneal Dystrophy XECD Endothelial Corneal Dystrophy, X-Linked
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2
Deafness, X-Linked 1	DFNX1 Dfn2 Deafness, X-Linked 2, Sensorineural Congenital X-Linked Deafness 1 X-Linked Sensorineural Congenital Deafness 2 Deafness, X-Linked, 1 Congenital Sensorineural Deafness X-Linked 2 Deafness, X-Linked, Type 1
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a	Leyden-Moebius Muscular Dystrophy Lgmd2a Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency Muscular Dystrophy, Limb-Girdle, Type 2a Pelvofemoral Muscular Dystrophy Primary Calpainopathy
Chondroblastic Osteosarcoma	Chondrosarcomatous Osteogenic Sarcoma
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS01892	CAPN6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAPN6	VGNC	VGNC:26749
Mus musculus	CAPN6	MGD	MGI:1100850
Macaca mulatta	CAPN6	VGNC	VGNC:70535
Rattus norvegicus	CAPN6	RGD	RGD:70960
Canis familiaris	CAPN6	VGNC	VGNC:38706
Felis catus	CAPN6	VGNC	VGNC:60356
Others	CAPN6	NCBI