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Cat. No.: HY-188125

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Globo H

Globo H is a carbohydrate antigen belonging to the globo-series glycosphingolipids, and its non-reducing terminal tetrasaccharide fragment serves as the core epitope recognized by antibodies. Globo H is upregulated in a variety of human cancer tissues, and is also present in some normal fetal and adult epithelial tissues. Globo H can be used in cancer-related research.

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CAS No.: 207384-96-1
화학식: C₃₈H₆₅NO₃₀
분자량:1015.91

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Globo H Chemical Structure

CAS No.: 207384-96-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Endogenous Metabolite Isoforms :

In Vitro

Globo H, in the forms of Globo H‑BSA and Globo H‑ceramide, binds strongly to mAb VK‑9. This antigen achieves optimal binding to mAb VK‑9 via its 4 non-reducing terminal sugar sequences, while internal α‑GalNAc linkage modifications reduce binding affinity. Mixed hemagglutination assays confirm that this antigen is highly expressed on the surface of MCF‑7 human breast cancer cells and binds strongly to mAb VK‑9. Immunocytochemical detection shows only weak binding to SK‑OV‑4 human ovarian cancer cells and T47D human breast cancer cells, with no binding observed in the other tested cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Globo H (10 μg; s.c.; at 0, 1, 2, 22, and 35 weeks) when administered as globo H-KLH conjugate plus QS21 adjuvant elicits an antibody response that recognizes globo H structures, including those on human tumor cells in female CB6F1 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 207384-96-1
분자량 1015.91
화학식 C₃₈H₆₅NO₃₀
SMILES

CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O[C@@H]2[C@H]([C@H](O[C@@H]([C@@H]2O)CO)O[C@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@H]([C@@H]([C@H]4O)O)O)CO)CO)O)CO)O)O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O)O[C@H]6[C@H]([C@@H]([C@@H]([C@@H](O6)C)O)O)O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kudryashov V, et al. Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate. Glycoconjugate journal. 1998 Mar;15(3):243-9.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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