GPV574
GPV574 is a derivative of the antiarrhythmic compound propafenone, capable of inhibiting HERG channels (IC50 = 5.04 μM).
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- CAS No.: 635703-12-7
- 화학식: C23H30N2O3
- 분자량:382.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 5.04 μM (HERG)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDR | EC50 |
1.349 μM
Compound: 123
|
Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay
Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay
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[PMID: 17352460] |
Chemical Information
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CAS No. 635703-12-7
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분자량 382.50
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화학식 C23H30N2O3
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SMILES
O=C(C)C1=CC=C(C=C1)OCC(CN2CCN(CC2)C3=CC=CC(C)=C3C)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPV574 Related Classifications
HY-169624 Related Classifications
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