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Cat. No.: HY-119232

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GSK466317A

GSK466317A is a PKA inhibitor, with an IC₅₀ of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC₅₀s of 1000, 31.62, and 39.81 μM, respectively.

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CAS No.: 864082-48-4
화학식: C₂₁H₁₆ClF₃N₄O₂
분자량:448.83

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

GSK466317A Chemical Structure

CAS No.: 864082-48-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GSK466317A is a PKA inhibitor, with an IC₅₀ of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC₅₀s of 1000, 31.62, and 39.81 μM, respectively^[1].

IC₅₀ & Target

^[1]

GRK2	PKA 12.59 μM (IC₅₀)

All PKA Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	8 nM Compound: 16	Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM Inhibition of human recombinant ROCK1 expressed in Sf9 cells at 10 mM	[PMID: 17201405]

Chemical Information

CAS No. 864082-48-4
분자량 448.83
화학식 C₂₁H₁₆ClF₃N₄O₂
SMILES

O=C(NC1=CC2=C(C(Cl)=C1)NN=C2)C3=C(NC(CC3C4=CC=C(C=C4)C(F)(F)F)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Homan KT, et, al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GSK466317A

All PKA Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GSK466317A Related Classifications

HY-119232 Related Classifications

Bioz

Keywords

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