Cat. No.: HY-156500

ICMT-IN-1

고객리뷰

Based on 1 Customer Validation

ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC₅₀=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.43%
CAS No.: 1313603-22-3
화학식: C₂₄H₃₃NO₂
분자량:367.52

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

ICMT-IN-1 Chemical Structure

CAS No.: 1313603-22-3

사이즈

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수량

Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 0.0013 μM (ICMT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	GI₅₀	0.3 μM Compound: 75	Cytotoxicity against human CCRF-CEM cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human CCRF-CEM cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
DU-145	GI₅₀	45 μM Compound: 75	Cytotoxicity against human DU145 cells expressing wild type Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human DU145 cells expressing wild type Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
HCT-116	GI₅₀	20 μM Compound: 75	Cytotoxicity against human HCT116 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human HCT116 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
HL-60	GI₅₀	3 μM Compound: 75	Cytotoxicity against human HL60 cells expressing N-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human HL60 cells expressing N-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
MIA PaCa-2	GI₅₀	19 μM Compound: 75	Cytotoxicity against human MIAPaCa2 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human MIAPaCa2 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
PC-3	GI₅₀	13 μM Compound: 75	Cytotoxicity against human PC3 cells expressing wild type Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human PC3 cells expressing wild type Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
SK-MEL-2	GI₅₀	>100 μM Compound: 75	Cytotoxicity against human SK-MEL-2 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human SK-MEL-2 cells expressing K-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]
T-24	GI₅₀	12 μM Compound: 75	Cytotoxicity against human T24 cells expressing N-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay Cytotoxicity against human T24 cells expressing N-Ras assessed as growth inhibition after 7 days by luminescence-based ATPlite assay	[PMID: 21661760]

Chemical Information

CAS No. 1313603-22-3
Appearance Solid
분자량 367.52
화학식 C₂₄H₃₃NO₂
Color Brown to reddish brown
SMILES

CC(C)(C1)OC(C)(C)CC1(C2=CC=CC=C2)CCNC3=CC(OC)=CC=C3
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (272.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7209 mL

13.6047 mL

27.2094 mL

5 mM

0.5442 mL

2.7209 mL

5.4419 mL

10 mM

0.2721 mL

1.3605 mL

2.7209 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT). J Med Chem. 2011 Jul 28;54(14):5031-47. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7209 mL	13.6047 mL	27.2094 mL	68.0235 mL
	5 mM	0.5442 mL	2.7209 mL	5.4419 mL	13.6047 mL
	10 mM	0.2721 mL	1.3605 mL	2.7209 mL	6.8024 mL
	15 mM	0.1814 mL	0.9070 mL	1.8140 mL	4.5349 mL
	20 mM	0.1360 mL	0.6802 mL	1.3605 mL	3.4012 mL
	25 mM	0.1088 mL	0.5442 mL	1.0884 mL	2.7209 mL
	30 mM	0.0907 mL	0.4535 mL	0.9070 mL	2.2675 mL
	40 mM	0.0680 mL	0.3401 mL	0.6802 mL	1.7006 mL
	50 mM	0.0544 mL	0.2721 mL	0.5442 mL	1.3605 mL
	60 mM	0.0453 mL	0.2267 mL	0.4535 mL	1.1337 mL
	80 mM	0.0340 mL	0.1701 mL	0.3401 mL	0.8503 mL
	100 mM	0.0272 mL	0.1360 mL	0.2721 mL	0.6802 mL

Keywords

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ICMT-IN-1

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ICMT-IN-1

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Anti-Cancer Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

ICMT-IN-1 Related Classifications

HY-156500 Related Classifications