Indisulam (Standard)
Indisulam (Standard) (E 7070 (Standard)) is the analytical standard of Indisulam (HY-13650). This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor and RBM39 molecular glue degrader, with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, respectively, and a Ki value of 65 nM against bovine carbonic anhydrase IV. Indisulam promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39. Indisulam induces aberrant pre-mRNA splicing, G1 cell cycle arrest, and cell death in cancer cells. As an anticancer agent, Indisulam drives tumor regression and growth inhibition in xenograft models. Indisulam can be used in research related to solid tumors, hematologic and lymphoid malignancies, colorectal cancer, and non-small cell lung cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98%
- CAS No.: 165668-41-7
- 화학식: C14H12ClN3O4S2
- 분자량:385.85
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- 순도&문서
-
Help & FAQs
-
HY-13650
IndisulamCarbonic Anhydrase Inhibitor/RBM39 Molecular Glue Degrader -
HY-13513
U-104CA IX/XII Inhibitor -
HY-B0782
AcetazolamideCA IX Inhibitor -
HY-B0397
DichlorphenamideCarbonic Anhydrase Inhibitor -
HY-B0553
MethazolamideCarbonic Anhydrase Inhibitor -
HY-B0588
BrinzolamideCarbonic Anhydrase II Inhibitor -
HY-B0122
TopiramateAntiepileptic Agent -
HY-B0109A
Dorzolamide hydrochlorideCarbonic Anhydrase II Inhibitor -
HY-B0782R
Acetazolamide (Standard) -
HY-101087
BenzenesulphonamideCA Inhibitor -
HY-B1480
EthoxzolamideCarbonic Anhydrase Inhibitor -
HY-B0483
TioxoloneCarbonic Anhydrase Inhibitor
Product Information
Information
신청
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 165668-41-7
-
분자량 385.85
-
화학식 C14H12ClN3O4S2
-
SMILES
O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O
-
Synonyms
E 7070 (Standard)
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorganic & medicinal chemistry letters. 2004 Jan 05;14(1):217-23. [Content Brief]
[2]. Han T, et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.). 2017 Apr 28;356(6336):eaal3755. [Content Brief]
[3]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. European journal of cancer (Oxford, England : 1990). 2001 Nov;37(17):2275-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indisulam (Standard) Related Classifications
HY-13650R Related Classifications
Powered by Bioz
Keywords
- Indisulam (Standard)
- 165668-41-7
- E 7070 (Standard)
- Reference Standards
- Molecular Glues
- Carbonic Anhydrase
- human carbonic anhydrase I
- CUL4-DCAF15 E3 ubiquitin ligase complex
- human carbonic anhydrase IX
- RBM39
- human carbonic anhydrase IV
- HCT-116 human colorectal carcinoma cells
- non-small cell lung cancer
- hematopoietic and lymphoid malignancies
- human carbonic anhydrase II
- colorectal cancer
- Inhibitor
- inhibitor
- inhibit