Isoprocurcumenol
Based on 1 Customer Validation
Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes.
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- Purity: 95.41%
- CAS No.: 102130-90-5
- 화학식: C15H22O2
- 분자량:234.33
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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ERK |
Akt |
Isoprocurcumenol (10 μM, 0-1 h) increases the phosphorylation of ERK and AKT[3].
Isoprocurcumenol (0-200 μM, 24 or 48 h) induces the proliferation of keratinocytes HaCaT cells[3].
Isoprocurcumenol (1 μM, 1 h) increases the expression of genes related to cell growth and proliferation, such as c-fos, c-jun, c-myc, and egr-1, through activation of the EGFR signaling pathway[3].
Isoprocurcumenol induces cell recovery and wound healing[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells (human keratinocyte cell)
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Concentration:10 μM
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Incubation Time:10, 30, or 60 min
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Result:Induced the phosphorylation of ERK and AKT after 10 min and this was sustained for 1 h.
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Cell Line:HaCaT cells (human keratinocyte cell)
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Concentration:0 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM, or 200 μM
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Incubation Time:24 or 48 h
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Result:Showed a significant increase in the proliferation of cells at most of the Isoprocurcumenol concentrations, starting at 10 nM.
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Cell Line:HaCaT cells (human keratinocyte cell)
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Concentration:1 μM
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Incubation Time:1 h
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Result:Increased the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1.
Chemical Information
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CAS No. 102130-90-5
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Appearance Solid
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분자량 234.33
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화학식 C15H22O2
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Color White to off-white
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SMILES
O=C1CC([C@]2([H])CC[C@](C)(O)[C@@]2([H])C/C1=C(C)\C)=C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 2.4 mg/mL (10.24 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (282 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4. [Content Brief]
[2]. Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414. [Content Brief]
[3]. Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22(22):12579. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.2675 mL | 21.3374 mL | 42.6749 mL | 106.6871 mL |
| 5 mM | 0.8535 mL | 4.2675 mL | 8.5350 mL | 21.3374 mL | |
| 10 mM | 0.4267 mL | 2.1337 mL | 4.2675 mL | 10.6687 mL |
Isoprocurcumenol Related Classifications
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