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Cat. No.: HY-156399

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KR-27425

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE).

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CAS No.: 3047755-18-7
화학식: C₁₀H₂₁N₃O₂
분자량:215.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

KR-27425 Chemical Structure

CAS No.: 3047755-18-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE)^[1].

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
HFL1	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
L929	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
NIH3T3	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]
Vero	CC₅₀	>100 μM Compound: 13; KR-27425	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37838342]

Chemical Information

CAS No. 3047755-18-7
분자량 215.29
화학식 C₁₀H₂₁N₃O₂
SMILES

CC(CCCNCCNC(/C=N/O)=O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vishakantegowda AG, et al. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129504. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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KR-27425

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KR-27425 Related Classifications

HY-156399 Related Classifications