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Cat. No.: HY-117182

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LG190178

LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.

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CAS No.: 233268-81-0
화학식: C₂₈H₄₂O₅
분자량:458.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

LG190178 Chemical Structure

CAS No.: 233268-81-0

사이즈

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All RAR/RXR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>10 μM Compound: 3a, LG190178, Diastereomeric mixture	Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of transcriptional activity by luciferase and beta-galactosidase reporter gene assay	[PMID: 23462715]
HL-60	EC₅₀	30 nM Compound: 3a, LG190178, Diastereomeric mixture	Induction of monocytic cell differentiation in human HL60 cells Induction of monocytic cell differentiation in human HL60 cells	[PMID: 23462715]
HL-60	ED₅₀	44 nM Compound: 7	Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation Vitamin D3 agonistic activity as effective dose for HL-60 monocytic cell differentiation	[PMID: 16019211]
LNCaP	EC₅₀	20 nM Compound: 3a, LG190178, Diastereomeric mixture	Growth inhibition of human LNCAP cells Growth inhibition of human LNCAP cells	[PMID: 23462715]
SC-3	IC₅₀	19 nM Compound: 7	Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation Androgen antagonistic activity as inhibitory concentration against testosterone-induced SC-3 cell proliferation	[PMID: 16019211]

Chemical Information

CAS No. 233268-81-0
분자량 458.63
화학식 C₂₈H₄₂O₅
SMILES

OCC(O)COC1=CC=C(C(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)(CC)CC)C=C1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Perakyla, et al. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Molecular endocrinology 19.8 (2005): 2060-2073. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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LG190178

All RAR/RXR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LG190178 Related Classifications

HY-117182 Related Classifications