LY-23
LY-23 is an orally active α-glucosidase inhibitor (Ki = 0.05 μM), with IC50 values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia.
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- 화학식: C19H27Cl3O7S
- 분자량:505.84
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
LY-23 (72 h) exhibits no significant in vitro cytotoxicity in HEK-293T and L02 cells at concentrations up to 400 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
LY-23 (1.0-10.0 mg/kg; p.o.; single administration) reduces postprandial blood glucose in sucrose-loaded mice. At the dose of 1.0 mg/kg, it decreases AUC0-t by 41.5%, while at 10.0 mg/kg, the reduction rate of AUC0-t reaches 48.1%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, SPF grade, 22-26 g)[1]
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Dosage:1.0 mg/kg
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Administration:p.o.; single dose
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Result:Reduced blood glucose levels by 54.3% at 15 minutes.
Reduced blood glucose levels by 58.1% at 30 minutes.
Reduced blood glucose levels by 44.3% at 60 minutes.
Reduced the area under the blood glucose curve (AUC) by 47.1% compared to the control group.
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Animal Model:ICR mice (male, SPF grade, 22-26 g)[1]
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Dosage:1.0 mg/kg; 10.0 mg/kg
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Administration:p.o.; single dose
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Result:Reduced blood glucose levels by 57.5% at 15 minutes, 53.3% at 30 minutes, 34.3% at 60 minutes, and reduced the AUC by 41.5% compared to the control group (1.0 mg/kg).
Reduced blood glucose levels by 57.0% at 15 minutes, 56.4% at 30 minutes, 47.0% at 60 minutes, and reduced the AUC by 48.1% compared to the control group (10.0 mg/kg).
Chemical Information
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분자량 505.84
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화학식 C19H27Cl3O7S
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SMILES
OC[C@@H]1[C@@H](O)[C@H](O)C[S@+]1C[C@H]([C@H]2O[C@H](C)[C@H](OCC3=CC(Cl)=CC=C3Cl)[C@H]2O)O.[Cl-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY-23 Related Classifications
HY-182289 Related Classifications
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