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Cat. No.: HY-101555

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M 16209

M 16209 is an orally active aldose reductase (AR) inhibitor. M 16209 inhibits partially purified AR from various sources with IC₅₀ values of 0.12, 0.24, 4.5, 1.2 and 9.3 μM for rat lens AR, bovine lens AR, bovine kidney AR, canine lens AR and human placental AR. M 16209 can be used for the research of metabolic disease, such as diabetes.

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CAS No.: 128851-36-5
화학식: C₁₁H₇BrN₂O₅S
분자량:359.15

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

M 16209 Chemical Structure

CAS No.: 128851-36-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

M 16209 (10-30 mg/kg, p.o., daily for 6 days) prevents galactose-induced cataracts in male Sprague-Dawley rats^[1].
M 16209 (10-30 mg/kg, p.o., daily for 14 days) ameliorates motor nerve conduction velocity delay in male Wistar rats with Streptozotocin (HY-13753)-induced diabetic neuropathy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 128851-36-5
분자량 359.15
화학식 C₁₁H₇BrN₂O₅S
SMILES

O=C1NC(CN1S(=O)(C2=C(Br)C3=CC=CC=C3O2)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kato K, et al. Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1540-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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