MGS 0210
MGS 0210 (BCI 838) is an orally active metabolite of glutamate receptor 2/3 (mGluR2/3) agonists. MGS 0210 improves amnesia and reduces anxiety in APP mice. MGS 0210 improves PTSD-related behaviors in a mouse model of post-traumatic stress disorder (PTSD). MGS 0210 can be used in research on neurological disorders such as Alzheimer's disease and major depressive disorder.
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- CAS No.: 820244-38-0
- 화학식: C22H28Cl2FNO5
- 분자량:476.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 820244-38-0
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분자량 476.37
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화학식 C22H28Cl2FNO5
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SMILES
CCCCCCCOC([C@@]1([C@]2([H])[C@@]1([H])C[C@@H](OCC3=CC(Cl)=C(Cl)C=C3)[C@@]2(N)C(O)=O)F)=O
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Synonyms
BCI 838
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Kim SH, et al.. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov;19(11):1235-42. [Content Brief]
[2]. Tschiffely AE,et al. Blast-induced "PTSD": Evidence from an animal model. Neuropharmacology. 2019 Feb;145(Pt B):220-229. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MGS 0210 Related Classifications
HY-108041 Related Classifications
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