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Cat. No.: HY-18612

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MK-7725

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC₅₀ of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC₅₀ of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity.

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CAS No.: 1034152-93-6
화학식: C₂₅H₁₉F₆N₅O₅S
분자량:615.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MK-7725 Chemical Structure

CAS No.: 1034152-93-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.6 nM Compound: 1, MK-7725	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	[PMID: 22494842]
CHO	IC₅₀	3.6 nM Compound: 14, MK-7725	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	[PMID: 24900461]
CHO-K1	EC₅₀	1.4 nM Compound: 2, MK-7725	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	130 nM Compound: 1b, MK-7725	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]
CHO-K1	EC₅₀	22 nM Compound: 2, MK-7725	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	73 nM Compound: 1b, MK-7725	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]

Chemical Information

CAS No. 1034152-93-6
분자량 615.50
화학식 C₂₅H₁₉F₆N₅O₅S
SMILES

O=S(C1=CC=C(C=C1)OC(F)(F)F)(N2C3=C(C4=NOC(C(C)(C)O)=N4)C=CC=C3NC5=NC(C(F)(F)F)=CC=C5C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chobanian HR, et al. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2012 Jan 21;3(3):252-6. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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