country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-162966

Copy Link Print Information

MS7829

MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits OTUB1 to cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3060519-67-4
화학식: C₄₄H₅₇Cl₂N₉O₆S
분자량:910.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MS7829 Chemical Structure

CAS No.: 3060519-67-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

MS7829 (0-10 μM; 0-24 h) stabilizes cGAS and elevates downstream STING protein levels in HeLa cells in vitro in a concentration- and time-dependent manner, without affecting cGAS transcription^[1].
MS7829 (5-10 μM; 24 h)-mediated cGAS stabilization and STING elevation in HeLa cells is dependent on specific binding to both cGAS and OTUB1^[1].
MS7829 (5 μM; 24 h) activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in an OTUB1-dependent manner, increasing cGAMP production and downstream cytokine gene expression^[1].
MS7829 (5 μM; days-2 weeks) potently suppresses HeLa cell proliferation and clonogenicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HeLa cells
Concentration:

5 μM
Incubation Time:

2 days (proliferation assay); 2 weeks (clonogenicity assay)
Result:

Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.

Chemical Information

CAS No. 3060519-67-4
분자량 910.95
화학식 C₄₄H₅₇Cl₂N₉O₆S
SMILES

ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CC(NCCCCCCCCCNC(CCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng Z, et al. The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS. Angew Chem Int Ed Engl. 2025;64(3):e202415168. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기