N-(E)-Caffeoyldopamine
N-(E)-Caffeoyldopamine is an inhibitor of α-glucosidase that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research.
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- CAS No.: 103188-49-4
- 화학식: C17H17NO5
- 분자량:315.32
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
229 μM
Compound: 8d
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Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 12 days by WST-1 assay
Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 12 days by WST-1 assay
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[PMID: 37216809] |
| PC-12 | CC50 |
>150 μM
Compound: 6i
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Cytotoxicity against rat PC12 cells measured for 24 hrs by WST-assay
Cytotoxicity against rat PC12 cells measured for 24 hrs by WST-assay
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[PMID: 38740144] |
Chemical Information
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CAS No. 103188-49-4
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Appearance Solid
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분자량 315.32
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화학식 C17H17NO5
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SMILES
OC=1C=CC(=CC1O)CCNC(/C=C/C2=CC(O)=C(O)C=C2)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Protocol
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
순도&문서
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Data Sheet (264 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-(E)-Caffeoyldopamine Related Classifications
HY-W127945 Related Classifications
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