Pentabromopseudilin
Based on 1 publication(s) in Google Scholar
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer.
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- Purity : 99.63%
- CAS No.: 10245-81-5
- 화학식: C10H4Br5NO
- 분자량:553.66
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pentabromopseudilin
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Biological Activity
제품 설명
In Vitro
Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) prevents TGF-β-induced Smad protein phosphorylation and nuclear translocation[1].
PBrP (0.5 μM, 6 h) inhibits TGF-β-stimulated transcriptional responses[1].
PBrP (0-1 μM, 6 h) inhibits TGF-β-induced EMT in A549 cells[1].
PBrP (0.2 μM, 20 h) suppresses TGF-β-induced cell migration[1].
PBrP (0.01-1 μM, 6 h) blocks TGF-β signalling by enhancing degradation of TβRII[1].
PBrP (0.5 μM, 0, 1, 3 h) blocks TGF-β signalling by enhancing degradation of TβRII via caveolae[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mv1Lu, A549, Clone 9 and HepG2 cells
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Concentration:0.01-1 μM (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5 μM (Mv1Lu, A549 and HepG2 cells)
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Incubation Time:6 h (Mv1Lu, A549, Clone 9 and HepG2 cells); 0.5, 1, 2, 4, 6 h (Mv1Lu, A549 and HepG2 cells)
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Result:Suppressed the TGF-β-stimulated Smad2/3 phosphorylation in a dose-dependent manner in these cell lines.
Prevented TGF-β induced the nuclear translocation of Smad2/3 and PBrP alone did not alter the localisation of Smad proteins.
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Cell Line:A549 cells
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Concentration:0.2 μM
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Incubation Time:6 h
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Result:Abolished TGF-β-induced Smad2/3 nuclear translocation.
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Cell Line:A549 cells
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Concentration:0.2 μM
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Incubation Time:20 h
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Result:Suppressed TGF-β-stimulated cell migration and did not close the wound.
Chemical Information
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CAS No. 10245-81-5
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Appearance Solid
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분자량 553.66
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화학식 C10H4Br5NO
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Color Off-white to gray
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SMILES
OC1=C(C2=C(Br)C(Br)=C(Br)N2)C=C(Br)C=C1Br
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Structure Classification
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Initial Source
Pseudomonas bromoutilis
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
In Vitro:
DMSO : ≥ 125 mg/mL (225.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8062 mL | 9.0308 mL | 18.0616 mL | 45.1541 mL |
| 5 mM | 0.3612 mL | 1.8062 mL | 3.6123 mL | 9.0308 mL | |
| 10 mM | 0.1806 mL | 0.9031 mL | 1.8062 mL | 4.5154 mL | |
| 15 mM | 0.1204 mL | 0.6021 mL | 1.2041 mL | 3.0103 mL | |
| 20 mM | 0.0903 mL | 0.4515 mL | 0.9031 mL | 2.2577 mL | |
| 25 mM | 0.0722 mL | 0.3612 mL | 0.7225 mL | 1.8062 mL | |
| 30 mM | 0.0602 mL | 0.3010 mL | 0.6021 mL | 1.5051 mL | |
| 40 mM | 0.0452 mL | 0.2258 mL | 0.4515 mL | 1.1289 mL | |
| 50 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9031 mL | |
| 60 mM | 0.0301 mL | 0.1505 mL | 0.3010 mL | 0.7526 mL | |
| 80 mM | 0.0226 mL | 0.1129 mL | 0.2258 mL | 0.5644 mL | |
| 100 mM | 0.0181 mL | 0.0903 mL | 0.1806 mL | 0.4515 mL |
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