Phytic acid hexasodium
Based on 1 publication(s) in Google Scholar
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.
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- CAS No.: 34367-89-0
- 화학식: C6H12Na6O24P6
- 분자량:791.93
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Phytic acid hexasodium
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Biological Activity
제품 설명
IC50 & Target
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Human Endogenous Metabolite |
Chemical Information
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CAS No. 34367-89-0
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분자량 791.93
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화학식 C6H12Na6O24P6
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SMILES
O=P(O)(O[Na])O[C@H]1[C@H]([C@H]([C@@H]([C@H]([C@@H]1OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O)OP(O)(O[Na])=O
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Synonyms
Inositol hexaphosphate hexasodium; SNF472
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Protocol
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
순도&문서
References
[1]. Perelló J, et al. SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels. J Nephrol. 2018 Apr;31(2):287-296. [Content Brief]
[2]. Zabirnyk A,et al. SNF472, a novel anti-crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vascul Pharmacol. 2019 Nov-Dec;122-123:106583. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phytic acid hexasodium Related Classifications
HY-N0814B Related Classifications
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